Urologia Internationalis
Original Paper
Failure of Cytotoxic Chemotherapy, 1983–1988, and the Emerging Role of Monoclonal Antibodies for Renal CancerYagoda A. · Bander N.H.James Buchanan Brady Foundation, Division of Urology, Department of Surgery, New York Hospital-Cornell University Medical Center, New York, N.Y., USA
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Article / Publication Details
Received: February 14, 1989
Accepted: March 14, 1989
Published online: January 29, 2010
Issue release date: 1989
Number of Print Pages: 8
Number of Figures: 0
Number of Tables: 0
ISSN: 0042-1138 (Print)
eISSN: 1423-0399 (Online)
For additional information: https://www.karger.com/UIN
Abstract
A review of 36 cytotoxic agents used singly in over 1,900 patients with renal cancer between 1983 and 1988 finds marginal antitumor activity, < 5–10%. The future role of monoclonal antibodies for therapy of this disease may offer some hope with the recent description of rather specific phenotypic expression, URO 10+/URO 8+, suggesting the cell origin of most renal tumors from the distal portion of the proximal tubule.
© 1989 S. Karger AG, Basel
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Article / Publication Details
Received: February 14, 1989
Accepted: March 14, 1989
Published online: January 29, 2010
Issue release date: 1989
Number of Print Pages: 8
Number of Figures: 0
Number of Tables: 0
ISSN: 0042-1138 (Print)
eISSN: 1423-0399 (Online)
For additional information: https://www.karger.com/UIN
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