Urologia Internationalis
Original Paper
Antispermatozoal Autoantibodies and Genital InfectionPradignac A. · Demand R.M. · Cranz C. · Clavert A.Groupe de Recherche sur l’lnfection Génitale, Cecos Alsace, Hôpital Civil de Strasbourg, France
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Article / Publication Details
Received: May 31, 1989
Accepted: March 06, 1990
Published online: February 02, 2010
Issue release date: 1991
Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 0
ISSN: 0042-1138 (Print)
eISSN: 1423-0399 (Online)
For additional information: https://www.karger.com/UIN
Abstract
The aim of this study was to evaluate why high levels of antispermatozoa autoantibodies (SPZAA) in seminal fluid represent a particularly detrimental factor in male fertility. We studied a population of 219 patients consulting us on conjugal sterility associated with an initial asthenospermia. We looked in each case for the presence of SPZAA at the surface of spermatozoa in the seminal fluid and in the serum. We found 31 patients positive for surface SPZAA, 26 of whom had urogenital infections. We also demonstrated statistically significant correlations between high levels of SPZAA in seminal fluid and both a reduction in ejaculate volume and a tendency to oligo-spermia. A similar correlation was found between the reduction in ejaculate volume and oligospermia. These results suggest that urogenital infection is at present the main cause of SPZAA production, that testicular damage is frequently associated with apparently isolated glandular damage, and above all that a high level of SPZAA in seminal fluid has a more detrimental effect on male fertility due to more severe genital (glandular and testicular) damage.
© 1991 S. Karger AG, Basel
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Article / Publication Details
Received: May 31, 1989
Accepted: March 06, 1990
Published online: February 02, 2010
Issue release date: 1991
Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 0
ISSN: 0042-1138 (Print)
eISSN: 1423-0399 (Online)
For additional information: https://www.karger.com/UIN
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