Urologia Internationalis

Original Paper

Prostate-Specific Antigen as a Marker of Bone Metastasis in Patients with Prostate Cancer

Wolff J.M.a · Bares R.b · Jung P.K.a · Buell U.b · Jakse G.a

Author affiliations

Departments of aUrology and bNuclear Medicine, Aachen University of Technology, Aachen, Germany

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Urol Int 1996;56:169–173

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: May 29, 1995
Accepted: August 16, 1995
Published online: February 03, 2010
Issue release date: 1996

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 0

ISSN: 0042-1138 (Print)
eISSN: 1423-0399 (Online)

For additional information: https://www.karger.com/UIN

Abstract

Objective: Staging in patients with newly diagnosed untreated cancer of the prostate has significant ramifications on the management ofthe disease. Currently measurement of the serum prostate-specific antigen (PSA) concentration and radionuclide bone scan are two important procedures in the metastatic workup of these patients. We retrospectively evaluated the efficacy of PSA as a staging marker to discriminate prostate cancer patients with bone metastases from those without bone metastases. Materials and Methods: In a retrospective study 158 prostate cancer patients with (n = 21) and without (n = 137) bone metastases were analyzed. In all patients the initial PSA measurement as well as the radionuclide bone scan were evaluated. Results: Patients with bone metastases demonstrated a median serum PSA concentration of 151 ng/ml and only 1 patient revealed a serum PSA concentration of < 10 ng/ml. This resulted in a negative predictive value of 98%. In addition 67% of these patients demonstrated a serum PSA concentration of > 100 ng/ml, which resulted in a positive predictive value of 74% and an overall accuracy of 92%. Conclusion: The serum PSA concentration seems to provide useful information with regard to the presence of bone metastasis in patients with newly diagnosed cancer of the prostate. A serum PSA value of < 10 ng/ml nearly excludes bone metastases, whereas a serum PSA value of > 100 ng/ml is highly predictive of bone metastases.

© 1996 S. Karger AG, Basel




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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: May 29, 1995
Accepted: August 16, 1995
Published online: February 03, 2010
Issue release date: 1996

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 0

ISSN: 0042-1138 (Print)
eISSN: 1423-0399 (Online)

For additional information: https://www.karger.com/UIN


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