Pediatric Neurosurgery
Case Report
Intracranial Germinoma Associated with Down’s SyndromeReport of 2 Cases Department of Neurosurgery, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Toyama, Japan
Keywords: GerminomaDown’s syndromeBrain tumor |
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Article / Publication Details
Published online: January 07, 1999
Issue release date: October 1998
Number of Print Pages: 4
Number of Figures: 4
Number of Tables: 0
ISSN: 1016-2291 (Print)
eISSN: 1423-0305 (Online)
For additional information: https://www.karger.com/PNE
Abstract
It is well known that Down’s syndrome is sometimes associated with leukemia. However, there have been only a few case reports of a relationship between Down’s syndrome and brain tumors. We report 2 cases with histological diagnoses of germinoma. The 1st case was a 10-year-old boy with Down’s syndrome complaining of seizure and left hemiparesis. Computed tomographic (CT) scan and magnetic resonance imaging (MRI) showed a mass lesion in the right basal ganglia and thalamus. Histological examination indicated two cell pattern germinomas. The 2nd case was a 20-year-old man with Down’s syndrome complaining of headache and vomiting. CT scan and MRI showed a pineal region tumor with marked hydrocephalus. Surgical specimens showed typical germinoma. Only 13 cases of brain tumors associated with Down’s syndrome have been reported. A higher incidence of germ cell tumors seems to be related to chromosomal abnormalities.
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Article / Publication Details
Published online: January 07, 1999
Issue release date: October 1998
Number of Print Pages: 4
Number of Figures: 4
Number of Tables: 0
ISSN: 1016-2291 (Print)
eISSN: 1423-0305 (Online)
For additional information: https://www.karger.com/PNE
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