Pediatric Neurosurgery

Original Paper

A Piglet Model for Evaluation of Cerebral Blood Flow and Brain Oxidative Metabolism during Gradual Cerebral Perfusion Pressure Decrease

Bauer R.a · Walter B.a · Torossian A.b · Fritz H.b · Schlonski O.a · Jochum T.a · Hoyer D.a · Reinhart K.b · Zwiener U.a

Author affiliations

aInstitute for Pathophysiology and bClinic for Anesthesiology and Intensive Care, Friedrich Schiller University, Jena, Germany

Keywords: Epidural balloon inflationColored microspheresCerebral metabolic rate of oxygenPiglets

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Pediatr Neurosurg 1999;30:62–69
https://doi.org/10.1159/000028765

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: April 29, 1999
Issue release date: February 1999

Number of Print Pages: 8
Number of Figures: 2
Number of Tables: 3

ISSN: 1016-2291 (Print)
eISSN: 1423-0305 (Online)

For additional information: https://www.karger.com/PNE

Abstract

A piglet model was developed to study the effect of epidural volume expansion on cerebral perfusion pressure (CPP) by stepwise elevating intracranial pressure (ICP). Mean arterial blood pressure (ABP) was strictly maintained using an extracorporeal ABP controller. Two-week-old piglets (n = 10) were studied by surgically placing an epidural balloon over the right parietal region and gradually increasing the inflation to increase ICP to 25, 35 and 45 mm Hg, maintaining each pressure level for 30 min. Regional cerebral blood flow was measured using the colored microsphere technique, and cerebral oxygen delivery and cerebral metabolic rate of oxygen were calculated at baseline conditions and after reaching ICP levels of 25, 35 and 45 mm Hg. The results showed that this model of epidural volume expansion reproducibly reduces CPP to 70, 50 and 33% of baseline CPP values with elevation of ICP, and that the physiological variables remained stable throughout each increase in ICP. We conclude that the model simulates the effects of an acute intracranial focal mass expansion and is well suited for the evaluation of different therapeutical strategies for increased ICP in newborns and infants.



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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: April 29, 1999
Issue release date: February 1999

Number of Print Pages: 8
Number of Figures: 2
Number of Tables: 3

ISSN: 1016-2291 (Print)
eISSN: 1423-0305 (Online)

For additional information: https://www.karger.com/PNE

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1999, Vol.30, No. 2

February 1999

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