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Review

Targeted HER2 Treatment in Advanced Gastric Cancer

Jørgensen J.T.

Author affiliations

Dx-Rx Institute, Fredensborg, Denmark

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Oncology 2010;78:26–33

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Article / Publication Details

First-Page Preview
Abstract of Review

Received: August 21, 2009
Accepted: March 11, 2009
Published online: February 25, 2010
Issue release date: March 2010

Number of Print Pages: 8
Number of Figures: 3
Number of Tables: 2

ISSN: 0030-2414 (Print)
eISSN: 1423-0232 (Online)

For additional information: https://www.karger.com/OCL

Abstract

Amplification of the HER2 gene and over-expression of the HER2 protein in gastric cancer have been shown in a large number of studies. HER2 positivity can be detected in approximately 20% of patients, which is a characteristic associated with poor prognosis. Preclinical in vitro and in vivo studies have demonstrated that both trastuzumab and lapatinib are effective in different gastric cancer models and have thus lead to the initiation of clinical studies. In the first phase III study, the ToGA trial, HER2-positive patients with advanced gastroesophageal and gastric adenocarcinoma were randomized to receive 5-fluorouracil/capecitabine and cisplatin either alone or in combination with trastuzumab. A statically significant gain in overall survival was seen in the patients who received the combined treatment of trastuzumab and chemotherapy. It is expected that the encouraging results from the ToGA trial will have an immediate impact on the management of patients and that routine HER2 testing of patients with advanced gastric cancer will be initiated within a relatively short period of time.

© 2010 S. Karger AG, Basel


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Article / Publication Details

First-Page Preview
Abstract of Review

Received: August 21, 2009
Accepted: March 11, 2009
Published online: February 25, 2010
Issue release date: March 2010

Number of Print Pages: 8
Number of Figures: 3
Number of Tables: 2

ISSN: 0030-2414 (Print)
eISSN: 1423-0232 (Online)

For additional information: https://www.karger.com/OCL


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