Transfusion Medicine and Hemotherapy

Review Article · Übersichtsarbeit

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Mesenchymal Stem or Stromal Cells: Toward a Better Understanding of Their Biology?

Lindner U.a · Kramer J.a,b · Rohwedel J.b · Schlenke P.c

Author affiliations

aMedical Department I, Division of Nephrology and Transplantation Unit, bDepartment of Virology and Cell Biology, University of Lübeck, cInstitute of Transfusion Medicine und Transplantation Immunology, Westphalian Wilhelms-University Münster, Germany

Corresponding Author

Dr. jur. Ulrich Lindner, Medical Department I, University of Lübeck, Ratzeburger Allee 160, 23538 Lübeck, Germany, Tel. +49 451 50060-20, Fax -22, Ulrich.Lindner@uk-sh.de

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Transfus Med Hemother 2010;37:75–83

Abstract

The adult bone marrow has been generally considered to be composed of hematopoietic tissue and the associated supporting stroma. Within the latter compartment, a subset of cells with multipotent differentiation capacity exists, usually referred to as mesenchymal stem cells. Mesenchymal stem cells can easily be expanded ex vivo and induced to differentiate into several cell types, including osteoblasts, adipocytes and chondrocytes. Up to now, mesenchymal stem cells have gained wide popularity. Despite the rapid growth in this field, irritations remain with respect to the defining characteristics of these cells, including their differentiation potency, self-renewal and in vivo properties. As a consequence, there is a growing tendency to challenge the term mesenchymal stem cell, especially with respect to the stem cell characteristics. Here, we revisit the experimental origins of mesenchymal stem cells, their classical differentiation capacity into mesodermal lineages and their immunophenotype in order to assess their stemness and function. Based on these essentials, it has to be revisited if the designation as a stem cell remains an appropriate term.

© 2010 S. Karger AG, Basel




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Article / Publication Details

First-Page Preview
Abstract of Review Article · Übersichtsarbeit

Received: February 03, 2010
Accepted: February 24, 2010
Published online: March 15, 2010
Issue release date: April 2010

Number of Print Pages: 9
Number of Figures: 0
Number of Tables: 0

ISSN: 1660-3796 (Print)
eISSN: 1660-3818 (Online)

For additional information: https://www.karger.com/TMH


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