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Original Paper

The Conditioned Stimulus Elicits Taste Aversion but Not Sickness Behavior in Conditioned Mice

Vidal J. · Chamizo V.D.

Author affiliations

University of Barcelona School of Psychology, Barcelona, Spain

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Neuroimmunomodulation 2010;17:325–332

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: April 14, 2009
Accepted: September 09, 2009
Published online: April 17, 2010
Issue release date: May 2010

Number of Print Pages: 8
Number of Figures: 3
Number of Tables: 1

ISSN: 1021-7401 (Print)
eISSN: 1423-0216 (Online)

For additional information: http://www.karger.com/NIM

Abstract

Objectives: This article extends previous reports on (i) elicitation of taste aversion after pairing a flavored beverage (saccharin solution) with a disease-provoking microbial product (lipopolysaccharide, LPS, or polyinosinic:polycytidylic acid, poly I:C); (ii) elicitation of sickness behavior (assessed as diminished ingestion of water and food) by the conditioned stimulus, and (iii) development of tolerance to those microbial products. Methods: Mice of the CD1 strain were conditioned by pairing ingestion of 0.15% saccharin solution with injection of LPS (100 µg/mouse) or poly I:C (6 mg/kg). A few days later, some mice were offered saccharin solution and were injected with saline, whereas other mice were offered saccharin solution and were injected with the microbial product. Results: Regardless of the nature of the unconditioned stimulus (LPS or poly I:C), (i) taste aversion to saccharin ensued, (ii) tolerance ensued to sickness elicitation by a second administration of the microbial component, and (iii) saccharin taste did not evoke sickness. Conclusions: Symptoms of infectious sickness in the absence of infection are hardly explained by exposure to the conditioned stimulus.

© 2010 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: April 14, 2009
Accepted: September 09, 2009
Published online: April 17, 2010
Issue release date: May 2010

Number of Print Pages: 8
Number of Figures: 3
Number of Tables: 1

ISSN: 1021-7401 (Print)
eISSN: 1423-0216 (Online)

For additional information: http://www.karger.com/NIM


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