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Original Paper

Clinical Effects of Preoperative Oestradiol Treatment before Vaginal Repair Operation

A Double-Blind, Randomized Trial

Mikkelsen A.L.a · Felding C.b · Clausen H.V.b

Author affiliations

aDepartment of Obstetrics and Gynaecology, University of Copenhagen, Gentofte County Hospital, Hellerup, and bDepartment of Obstetrics and Gynaecology, University of Copenhagen, Glostrup County Hospital, Glostrup, Denmark

Related Articles for ""

Gynecol Obstet Invest 1995;40:125–128

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: June 15, 1994
Accepted: February 06, 1995
Published online: March 01, 2010
Issue release date: 1995

Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 0

ISSN: 0378-7346 (Print)
eISSN: 1423-002X (Online)

For additional information: https://www.karger.com/GOI

Abstract

The objective of the study was to assess the effects of low-dose vaginal treatment with oestradiol before vaginal operation. In a double-blind randomized study including 43 postmenopausal women scheduled for vaginal repair operation for genital descensus, it was found that 7 patients suffered from concomitant urinary stress incontinence. Vagifem® (25 µg oestradiol) or placebo was administered as vaginal pessaries daily, 3 weeks prior to surgery and the clinical effects evaluated. One month postoperatively the prevalence of bacteriuria ( > 100,000 CFU/ml urine) was significantly lower when using oestradiol than in the placebo group. At follow-up 3 years later 40 women (93%) answered the questionnaires. None received hormone replacement therapy. Nineteen percent in the preoperative oestradiol group and 11% in the preoperative placebo group had had more than two episodes of cystitis treated with antibiotics. This difference is not statistically significant (p > 0.05). Recurrent cystitis was not correlated to bacteriuria postoperatively. Seventy-nine percent of the women with genital prolapse but only 29% of the women with concomitant urinary stress incontinence were cured (p < 0.05). Neither preoperative oestradiol treatment nor body weight had any influence on relapse. Preoperative low-dose vaginal oestradiol treatment may reduce the incidence of bacteriuria in the immediate postoperative period but no long-lasting effects on recurrent cystitis or relapse were seen. Longer-lasting hormone replacement therapy may be necessary to achieve lasting effects.

© 1995 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: June 15, 1994
Accepted: February 06, 1995
Published online: March 01, 2010
Issue release date: 1995

Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 0

ISSN: 0378-7346 (Print)
eISSN: 1423-002X (Online)

For additional information: https://www.karger.com/GOI


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