Gynecologic and Obstetric Investigation

Original Paper

A Randomized Study Comparing the Efficacy of Reducing the Spontaneous Abortion Rate following Lymphocyte Immunotherapy and Progesterone Treatment versus Progesterone Alone in Primary Habitual Aborters

Check J.H. · Tarquini P. · Gandy P. · Lauer C.

Author affiliations

Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School at Camden, Cooper Hospital/University Medical Center, Camden, N.J., USA

Related Articles for ""

Gynecol Obstet Invest 1995;39:257–261

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: August 29, 1994
Accepted: October 25, 1994
Published online: March 01, 2010
Issue release date: 1995

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 0

ISSN: 0378-7346 (Print)
eISSN: 1423-002X (Online)

For additional information: https://www.karger.com/GOI

Abstract

Presented herein is a randomized prospective study performed to evaluate the efficacy of the addition of lymphocyte immunotherapy (LI) to progesterone (P) therapy (LI/P) for the prevention of spontaneous abortion (SAB) in primary aborters with a history of three SABs. The incidence of intrauterine pregnancies in four cycles was 23 of 35 (65.7%) patients for LI/P vs. 14 of 31 (45.1%) patients treated with progesterone alone. SABs occurred in 6 of 23 (26.0%) Ll/P-treated patients compared to 8 of 14 (57.1%) given progesterone alone. The mean number of previous abortions in both groups was 3.9. The mean age of the LI/P group was 34.1 vs. 33.6 years for the group treated with progesterone alone. These data could be interpreted to show that progesterone therapy and LI independently inhibit SAB or that LI/P acts synergistically to inhibit immune destruction. LI/P therapy was found to be more effective than progesterone therapy alone.

© 1995 S. Karger AG, Basel




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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: August 29, 1994
Accepted: October 25, 1994
Published online: March 01, 2010
Issue release date: 1995

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 0

ISSN: 0378-7346 (Print)
eISSN: 1423-002X (Online)

For additional information: https://www.karger.com/GOI


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