Gynecologic and Obstetric Investigation
Original Paper
Relationship between Blood Gas Values and Hormonal Response to Acute Hypoxemia in Fetal SheepAkagi K. · Challis J.R.G.Medical Research Council Group in Fetal and Neonatal Health and Development, Lawson Research Institute, St. Joseph’s Health Centre, Department of Obstetrics and Gynecology and Department of Physiology, University of Western Ontario, London, Ont, Canada
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Article / Publication Details
Received: March 09, 1990
Accepted: April 05, 1990
Published online: March 02, 2010
Issue release date: 1990
Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 0
ISSN: 0378-7346 (Print)
eISSN: 1423-002X (Online)
For additional information: https://www.karger.com/GOI
Abstract
We examined the relationship of fetal plasma immunoreactive adrenocorticotropic hormone (IR-ACTH), arginine vasopressin (AVP) and cortisol to fetal arterial pO2 (PaO2), oxygen saturation (SaO2), change (Δ) in PaO2 (ΔPaO2) or SaO2 (ΔSaO2) in fetal sheep at 125–139 days of gestational age. Fetal sheep were exposed to two levels of hypoxemia induced by altering the inspired percent oxygen to the mother for 1 h without fetal acidemia. Fetal carotid arterial IR-ACTH, AVP and cortisol concentrations during hypoxemia were correlated with fetal PaO2, SaO2 ΔPaO2 and ΔSaO2 by applying simple regression analysis. For IR-ACTH, a strong correlation was obtained with SaO2, ΔSaO2 and ΔPaO2 after log transformation to IR-ACTH. For AVP, strong correlation coefficients were obtained with ΔSaO2, SaO2 ΔPaO2 and PaO2 after reciprocal transformation to AVP, but for cortisol a strong correlation was obtained only with ΔPaO2 after log transformation to cortisol. We conclude that during fetal hypoxemia without acidemia, there is a strong correlation between IR-ACTH and SaO2 ΔSaO2, ΔPaO2 but not PaO2, between AVP and ΔSaO2, SaO2, ΔPaO2 or PaO2, and between cortisol and ΔPaO2.
© 1990 S. Karger AG, Basel
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Article / Publication Details
Received: March 09, 1990
Accepted: April 05, 1990
Published online: March 02, 2010
Issue release date: 1990
Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 0
ISSN: 0378-7346 (Print)
eISSN: 1423-002X (Online)
For additional information: https://www.karger.com/GOI
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