Gynecologic and Obstetric Investigation

Original Paper

Relationship between Blood Gas Values and Hormonal Response to Acute Hypoxemia in Fetal Sheep

Akagi K. · Challis J.R.G.

Author affiliations

Medical Research Council Group in Fetal and Neonatal Health and Development, Lawson Research Institute, St. Joseph’s Health Centre, Department of Obstetrics and Gynecology and Department of Physiology, University of Western Ontario, London, Ont, Canada

Related Articles for ""

Gynecol Obstet Invest 1990;30:65–70

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: March 09, 1990
Accepted: April 05, 1990
Published online: March 02, 2010
Issue release date: 1990

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 0

ISSN: 0378-7346 (Print)
eISSN: 1423-002X (Online)

For additional information: https://www.karger.com/GOI

Abstract

We examined the relationship of fetal plasma immunoreactive adrenocorticotropic hormone (IR-ACTH), arginine vasopressin (AVP) and cortisol to fetal arterial pO2 (PaO2), oxygen saturation (SaO2), change (Δ) in PaO2 (ΔPaO2) or SaO2 (ΔSaO2) in fetal sheep at 125–139 days of gestational age. Fetal sheep were exposed to two levels of hypoxemia induced by altering the inspired percent oxygen to the mother for 1 h without fetal acidemia. Fetal carotid arterial IR-ACTH, AVP and cortisol concentrations during hypoxemia were correlated with fetal PaO2, SaO2 ΔPaO2 and ΔSaO2 by applying simple regression analysis. For IR-ACTH, a strong correlation was obtained with SaO2, ΔSaO2 and ΔPaO2 after log transformation to IR-ACTH. For AVP, strong correlation coefficients were obtained with ΔSaO2, SaO2 ΔPaO2 and PaO2 after reciprocal transformation to AVP, but for cortisol a strong correlation was obtained only with ΔPaO2 after log transformation to cortisol. We conclude that during fetal hypoxemia without acidemia, there is a strong correlation between IR-ACTH and SaO2 ΔSaO2, ΔPaO2 but not PaO2, between AVP and ΔSaO2, SaO2, ΔPaO2 or PaO2, and between cortisol and ΔPaO2.

© 1990 S. Karger AG, Basel




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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: March 09, 1990
Accepted: April 05, 1990
Published online: March 02, 2010
Issue release date: 1990

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 0

ISSN: 0378-7346 (Print)
eISSN: 1423-002X (Online)

For additional information: https://www.karger.com/GOI


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