Gynecologic and Obstetric Investigation
Original Paper
Human Recombinant Interleukin-lα Increases Elastase-Like Enzyme in Human Uterine Cervical FibroblastsIto A.a · Leppert P.C.b · Mori Y.aaDepartment of Biochemistry, Tokyo College of Pharmacy, Hachioji, Tokyo, Japan, and bDepartment of Obstetrics and Gynecology, University of Rochester, N.Y., USA
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Article / Publication Details
Received: April 10, 1990
Accepted: July 11, 1990
Published online: March 02, 2010
Issue release date: 1990
Number of Print Pages: 3
Number of Figures: 0
Number of Tables: 0
ISSN: 0378-7346 (Print)
eISSN: 1423-002X (Online)
For additional information: https://www.karger.com/GOI
Abstract
Production of the elastase-like enzyme, Suc-(Ala)3-p-nitroanilide hydrolase, was examined in human uterine cervical fibroblasts. The metallo-dependent enzyme is present in both media and cellular fractions. Human recombinant interleukin-lΑ stimulated cells to produce and secrete this elastase-like enzyme. These results suggest that modulation of this enzyme activity by interleukin-1 may play a significant role in the ripening and dilation of the cervix, because elastin is a component of the uterine cervix and its peptides are known to be chemotactic for leukocytes.
© 1990 S. Karger AG, Basel
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Article / Publication Details
Received: April 10, 1990
Accepted: July 11, 1990
Published online: March 02, 2010
Issue release date: 1990
Number of Print Pages: 3
Number of Figures: 0
Number of Tables: 0
ISSN: 0378-7346 (Print)
eISSN: 1423-002X (Online)
For additional information: https://www.karger.com/GOI
Copyright / Drug Dosage / Disclaimer
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