Cytogenetic and Genome Research
Relationship between DNA Repair and Formation of Sister Chromatid Exchanges and Chromatid Aberrations under the Influence of Poly(ADP-Ribose) Polymerase Inhibition by 3-AminobenzamideFilippi S.a · Palitti F.a · Martínez-López W.a, c · Fiore M.b · Natarajan A.T.aaDepartment of Agrobiology and Agrochemistry, University of Tuscia, Viterbo, and bInstitute of Molecular Biology and Pathology, CNR, Department of Genetics and Molecular Biology, University La Sapienza, Rome, Italy; cEpigenetics and Genomic Instability Laboratory, Instituto de Investigaciones Biológicas Clemente Estable, Montevideo, Uruguay
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Cytogenet Genome Res 2010;128:118–123
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Article / Publication Details
First-Page Preview
Published online: April 09, 2010
Issue release date: May 2010
Number of Print Pages: 6
Number of Figures: 1
Number of Tables: 3
ISSN: 1424-8581 (Print)
eISSN: 1424-859X (Online)
For additional information: https://www.karger.com/CGR
Abstract
The mechanisms of formation of sister chromatid exchanges (SCEs) and chromosome aberrations following inhibition of poly(ADP-ribose) polymerase by 3-aminobenzamide were studied in Chinese hamster ovary cell lines deficient in different repair pathways. The results confirm earlier findings that (a) the ‘spontaneous’ SCEs are formed due to the incorporated BrdU in the DNA, (b) ‘spontaneous’ and induced SCEs originate from different mechanisms, and (c) SCEs and chromatid exchanges are formed by different pathways.
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Article / Publication Details
First-Page Preview
Published online: April 09, 2010
Issue release date: May 2010
Number of Print Pages: 6
Number of Figures: 1
Number of Tables: 3
ISSN: 1424-8581 (Print)
eISSN: 1424-859X (Online)
For additional information: https://www.karger.com/CGR
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