Synopsis of Preterm Birth Genetic Association Studies: The Preterm Birth Genetics Knowledge Base (PTBGene)Dolan S.M.a, o · Hollegaard M.V.b, o · Merialdi M.c, o · Betran A.P.c, o · Allen T.d · Abelow C.a · Nace J.e, o · Lin B.K.f · Khoury M.J.g · Ioannidis J.P.A.h, i · Bagade S.j · Zheng X.k · Dubin R.A.k · Bertram L.j, l · Velez Edwards D.R.m, o · Menon R.c, e, n, o
aDepartment of Obstetrics and Gynecology and Women’s Health, Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, N.Y., USA; bSection of Neonatal Screening and Hormones, Statens Serum Institute, Copenhagen, Denmark; cDepartment of Reproductive Health and Research and dDepartment of Knowledge, Management and Sharing, World Health Organization, Geneva, Switzerland; eThe Perinatal Research Center, Nashville, Tenn., fOffice of the Medical Director, March of Dimes, White Plains, N.Y., gNational Office of Public Health Genomics, Centers for Disease Control and Prevention, Atlanta, Ga., USA; hDepartment of Hygiene and Epidemiology, University of Ioannina School of Medicine, and Biomedical Research Institute, Foundation for Research and Technology – Hellas, Ioannina, Greece; iCenter for Genetic Epidemiology and Modeling, Tufts Medical Center, and Department of Medicine, Tufts University School of Medicine, Boston, Mass., jGenetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease (MIND), Department of Neurology, Massachusetts General Hospital, Charlestown, Mass., kBioinformatics Shared Resource (BISR), Albert Einstein College of Medicine, Bronx, N.Y., USA; lNeuropsychiatric Genetics Group, Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin, Germany; mVanderbilt Epidemiology Center, Institute of Medicine and Public Health, Department of Obstetrics and Gynecology, Vanderbilt University, Nashville, Tenn., nDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Ga., oPREBIC Genetic Working Group 2007, USA
Do you have an account?
- Rent for 48h to view
- Buy Cloud Access for unlimited viewing via different devices
- Synchronizing in the ReadCube Cloud
- Printing and saving restrictions apply
Rental: USD 8.50
Cloud: USD 20.00
Article / Publication Details
Aim: Our goal wasto produce a field synopsis of genetic associations with preterm birth and to set up a publicly available online database summarizing the data. Methods: We performed a systematic review and meta-analyses to identify genetic associations with preterm birth. We have set up a publicly available online database of genetic association data on preterm birth called PTBGene (http://ric.einstein.yu.edu/ptbgene/index.html) and report on a structured synopsis thereof as of December 1, 2008. Results: Data on 189 polymorphisms in 84 genes have been included and 36 meta-analyses have been performed. Five gene variants (4 in maternal DNA, one in newborn DNA) have shown nominally significant associations, but all have weak epidemiological credibility. Conclusion: After publishing this field synopsis, the PTBGene database will be regularly updated to keep track of the evolving evidence base of genetic factors in preterm birth with the goal of promoting knowledge sharing and multicenter collaboration among preterm birth research groups.
© 2010 S. Karger AG, Basel
Article / Publication Details
Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.