Feasibility and Efficiency of Indirect Lifestyle Interventions in Offspring of Type 2 Diabetic PatientsNishigaki M.a · Ota A.b · Kusakabe T.a · Matsuzaki C.c · Taguchi S.c · Kazuma K.a
aThe Graduate School of Medicine, School of Health Sciences and Nursing, Department of Adult Nursing/Palliative Care Nursing, The University of Tokyo, Tokyo, bFukuyama Transporting Shibuya Longevity Health Foundation and cBrain Attack Center, Ota Medical Hospital, Fukuyama, Japan
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Introduction: Individuals genetically predisposed to type 2 diabetes represent an important target for preventive strategies. Genetic screening, based on information about individual genetic variants, will be possible technically, but translational research in this field is still insufficient. Family history thus represents a useful tool for detecting genetically high-risk populations in this post-genomic era. Objectives: The purpose of this pilot study was to investigate the feasibility and efficiency of indirect lifestyle interventions in offspring of type 2 diabetic patients. Methods: Offspring were recruited from 74 diabetic (Group 1) and 39 non-diabetic (Group 2, control group) patients. A lifestyle intervention was conducted by mail, a total of 3 times, every 3 months. Lifestyle related to diet and physical activity was assessed using a self-administered questionnaire. Results: Ten offspring of type 2 diabetic and 6 of non-diabetic patients participated in this study. Total energy intake decreased after 3 interventions in both of the groups (Group 1: 305 ± 228.8 kcal/day, p = 0.004; Group 2: 82 ± 65.6 kcal/day, p = 0.04); however, the effect of intervention was significantly greater in Group 1 compared to Group 2 (p = 0.021). Physical activity and other physical outcomes were stable in normal levels during the study period in both of the groups. Conclusions: The intervention program helped to reduce total energy intake in offspring of type 2 diabetic patients more than in the control group, but the acceptance rate of the intervention program was disappointingly low. Further consideration is required to access and motivate offspring to develop precautionary lifestyle principles.
© 2010 S. Karger AG, Basel
- Lango H; UK Type 2 Diabetes Genetics Consortium, Palmer CNA, Morris AD, Zeggini E, Hattersley AT, McCarthy MI, Frayling TM, Weedon MN: Assessing the combined impact of 18 common genetic variants of modest effect sizes on type 2 diabetes risk. Diabetes 2008;57:3129–3135.
- Meigs JB, Shrader P, Sullivan LM, McAteer JB, Fox CS, Dupuis J, Manning AK, Florez JC, Wilson PWF, D’Agostino RB Sr, Cupples LA: Genotype score in addition to common risk factors for prediction of type 2 diabetes. N Engl J Med 2008;359:2208–2219.
- Lyssenko V, Jonsson A, Almgren P, Pulizzi N, Isomaa B, Tuomi T, Berglund G, Altshuler D, Nilsson P, Groop L: Clinical risk factors, DNA variants, and the development of type 2 diabetes. N Engl J Med 2008;359:2220–2232.
- Kuzuya T, Matsuda A: Family histories of diabetes among Japanese patients with type 1 (insulin-dependent) and type 2 (non-insulin-dependent) diabetes. Diabetologia 1982;22:372–374.
- Valdez R, Yoon PW, Liu T, Khoury MJ: Family history and prevalence of diabetes in the U.S. population: the 6-year results from the National Health and Nutrition Examination Survey (1999–2004). Diabetes Care 2007;30:2517–2522.
- Scheuner MT, Sieverding P, Shekelle PG: Delivery of genomic medicine for common chronic adult diseases: a systematic review. JAMA 2008;299:1320–1334.
- Khoury MJ, Gwinn M, Yoon PW, Dowling N, Moore CA, Bradley L: The continuum of translation research in genomic medicine: how can we accelerate the appropriate integration of human genome discoveries into health care and disease prevention? Genet Med 2007;9:665–674.
- Harrison TA, Hindorff LA, Kim H, Wines RC, Bowen DJ, McGrath BB, Edwards KL: Family history of diabetes as a potential public health tool. Am J Prev Med 2003;24:152–159.
- Hariri S, Yoon PW, Qureshi N, Valdez R, Scheuner MT, Khoury MJ: Family history of type 2 diabetes: a population-based screening tool for prevention? Genet Med 2006;8:102–108.
- Hariri S, Yoon PW, Moonesinghe R, Valdez R, Khoury MJ: Evaluation of family history as a risk factor and screening tool for detecting undiagnosed diabetes in a nationally representative survey population. Genet Med 2006;8:752–759.
Leventhal H, Nerenz D, Steele DJ: Illness representations and coping with health threats; in Baum A, Taylor SE, Singer JE (eds): A Handbook of Psychology and Health. Hillsdale, NJ, Lawrence Erlbaum Associates, 1984, pp 219–252.
- Leventhal H, Weinman J, Leventhal EA, Phillips LA: Health psychology: the search for pathways between behavior and health. Annu Rev Psychol 2008;59:477–505.
- Kadowaki T, Hara K, Yamauchi T, Terauchi Y, Tobe K, Nagai R: Molecular mechanism of insulin resistance and obesity. Exp Biol Med (Maywood) 2003;228:1111–1117.
Matsuoka K: Genetic and environmental interaction in Japanese type 2 diabetics. Diabetes Res Clin Pract 2000;50(suppl 2):17–22.
- Nishigaki M, Kobayashi K, Hitomi T, Yokomura T, Yokoyama M, Seki N, Kazuma K: Perception of offspring risk for type 2 diabetes, among patients with type 2 diabetes and their adult offsprings. Diabetes Care 2007;30:3033–3034.
- Nishigaki M, Kobayashi K, Abe Y, Seki N, Yokomura T, Yokoyama M, Kazuma K: Preventive behaviour in adult offspring of type 2 diabetic patients and its relationship to parental advice. Diabet Med 2008;25:1343–1348.
- Pierce M, Harding D, Ridout D, Keen H, Bradley C: Risk and prevention of type II diabetes: offspring’s views. Br J Gen Pract 2001;51:194–199.
- Brekke HK, Jansson PA, Mansson JE, Lenner RA: Lifestyle changes can be achieved through counseling and follow-up in first-degree relatives of patients with type 2 diabetes. J Am Diet Assoc 2003;103:835–843.
- Brekke HK, Jansson PA, Lenner RA: Long-term (1- and 2-year) effects of lifestyle intervention in type 2 diabetes relatives. Diabetes Res Clin Pract 2005;70:225–234.
- Knowler WC, Barrett-Connor E, Fowler SE, Hamman RF, Lachin JM, Walker EA, Nathan DM; Diabetes Prevention Program Research Group: Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med 2002;346:393–403.
- Tuomilehto J, Lindstrom J, Eriksson JG, Valle TT, Hamalainen H, Ilanne-Parikka P, Keinanen-Kiukaanniemi S, Laakso M, Louheranta A, Rastas M, Salminen V, Uusitupa M: Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. N Engl J Med 2001;344:1343–1350.
- Ishida S, Ito C, Murakami F: Prevention of type 2 diabetes mellitus by changing life-styles among high risk persons: the Diabetes Prevention Program in Hiroshima (DPPH)[in Japanese]. Nippon Rinsho 2005;63(suppl 2):578–581.
- Okayama A, Nohara M: Diabetes prevention program of healthy Japan 21 [in Japanese]. Nippon Rinsho 2002;60(suppl 10):613–619.
- Sakane N: Japan Diabetes Prevention Program [in Japanese]. Nippon Rinsho 2005;63(suppl 2):488–492.
Nishigaki M, Kobayashi K, Shibayama T, Kadowaki T, Kazuma K: Attitude of diabetes care specialists to prevention of diabetes to relatives of patients with type 2 diabetes [in Japanese]. J Jpn Diabetes Soc 2006;49:669–676.
- Castro CM, King AC: Telephone-assisted counseling for physical activity. Exerc Sport Sci Rev 2002;30:64–68.
- Sherwood NE, Morton N, Jeffery RW, French SA, Neumark-Sztainer D, Falkner NH: Consumer preferences in format and type of community-based weight control programs. Am J Health Promot 1998;13:12–18.
Yamatsu K, Adachi Y, Kumagai S: A development, evaluation, and usefulness of medical behavioral weight control program. J Health Sci 2005;27:13–25.
- Yamaoka K, Tango T, Watanabe M, Yokotsuka M: Validity and reproducibility of a semi-quantitative food frequency questionnaire for nutritional education of patients of diabetes mellitus (FFQW65) [in Japanese]. Nippon Koshu Eisei Zasshi 2000;47:230–244.
Naito Y, Harada A, Inoue S, Yoshinori K, Arao T, Ohashi Y: Report of the physical activity research of the Japan Arteriosclerosis Longitudinal Study [in Japanese]. Res Exerc Epidemiol 2003;5:1–8.
- Watanabe M, Yamaoka K, Yokotsuka M, Tango T: Randomized controlled trial of a new dietary education program to prevent type 2 diabetes in a high-risk group of Japanese male workers. Diabetes Care 2003;26:3209–3214.
- Pate RR, Pratt M, Blair SN, Haskell WL, Macera CA, Bouchard C, Buchner D, Ettinger W, Heath GW, King AC, et al: Physical activity and public health. A recommendation from the Centers for Disease Control and Prevention and the American College of Sports Medicine. JAMA 1995;273:402–407.
- Bonomo K, Fiora E, Caccavale A, Traversa M, Chirio M, Marchesini G, Trovati M: Diabetes prevention strategy in offspring of type 2 diabetic patients with a direct involvement of the diseased parents. Nutr Metab Cardiovasc Dis 2005;15:237–238.
- Adamson AJ, Foster E, Butler TJ, Bennet S, Walker M: Non-diabetic relatives of type 2 diabetic families: dietary intake contributes to the increased risk of diabetes. Diabet Med 2001;18:984–990.
- Delahanty LM, Conroy MB, Nathan DM: Psychological predictors of physical activity in the diabetes prevention program. J Am Diet Assoc 2006;106:698–705.
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