Gynecologic and Obstetric Investigation
Original Paper
Leiomyosarcoma of the Uterus: Ultrasonography and Serum Lactate Dehydrogenase LevelSeki K. · Hoshihara T. · Nagata I.Department of Obstetrics and Gynecology, National Defense Medical College, Tokorozawa, Saitama, Japan
Dr. Katsuyoshi Seki, Department of Obstetrics and Gynecology, National Defense Medical College, Namiki 3-2, Tokorozawa, Saitama 359 (Japan) |
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Abstract
Between January 1 1979, and September 30, 1990, a total of 1,886 patients in the National Defense Medical College Hospital, a self-referred population, had a hysterectomy because of signs and symptoms presumably resulting from uterine myomas. After hysterectomy with presumed benign disease, a histologic diagnosis of leiomyosarcoma was made in 7 patients (0.37%). Preoperative diagnosis of leiomyosarcoma was not made in any of the 7 patients. However, serum lactate dehydrogenase levels were abnormally elevated in 3 of them, and degenerative changes were found within the tumor by ultrasonography in 5 of them. Furthermore, increased lactate dehydrogenase levels and degenerative changes within the tumor were found in 3 of the patients whose tumors had 10 or more mitoses per 10 high-power fields. The prognosis for the leiomyosarcomas with increased mitotic rates is very poor. Therefore, a degenerative change within the uterine mass and an increased lactate dehydrogenase level, when present, should suggest the diagnosis of leiomyosarcoma.
© 1992 S. Karger AG, Basel
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Article / Publication Details
Received: May 21, 1991
Accepted: August 06, 1991
Published online: August 06, 2010
Issue release date: 1992
Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 0
ISSN: 0378-7346 (Print)
eISSN: 1423-002X (Online)
For additional information: https://www.karger.com/GOI
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