Original Research Article
In vivo Noninvasive Evaluation of Hairless Rat Skin after High-Voltage Pulse ExposureVanbever R.a · Fouchard D.b · Jadoul A.a · De Morre N.a · Préat V.a · Marty J.-P.ba Unité de Pharmacie Galénique, Ecole de Pharmacie, Université catholique de Louvain, Bruxelles, Belgique; b Unité de Recherche en Dermopharmacologie et Cosmétologie, Faculté de Pharmacie, Université de Paris Sud, Châtenay-Malabry, France
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Skin Pharmacol Appl Skin Physiol 1998;11:23–34
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Article / Publication Details
First-Page Preview
Published online: April 01, 1998
Issue release date: January – February
Number of Print Pages: 12
Number of Figures: 4
Number of Tables: 0
ISSN: 1660-5527 (Print)
eISSN: 1660-5535 (Online)
For additional information: https://www.karger.com/SPP
Abstract
Short high-voltage pulses have recently been shown to dramatically increase and expedite transdermal drug transport via a mechanism hypothesized to involve electroporation. This study addresses tolerance issues of the method in vivo in hairless rat. Chromametry, transepidermal water loss (TEWL), laser Doppler flowmetry (LDF) and corneometry were jointly used for noninvasive sensing of skin biophysical parameters. Slight increases in skin redness, TEWL and LDF values followed the application of electric pulses. The changes in skin capacitance were nonsignificant. The magnitude of the alterations depended on the electrical features of the pulses. When compared to iontophoresis, high-voltage pulses did not induce stronger alterations of skin functions. This report provides the first in vivo demonstration of the safety of the high-voltage pulses proposed for transdermal delivery.
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Article / Publication Details
First-Page Preview
Published online: April 01, 1998
Issue release date: January – February
Number of Print Pages: 12
Number of Figures: 4
Number of Tables: 0
ISSN: 1660-5527 (Print)
eISSN: 1660-5535 (Online)
For additional information: https://www.karger.com/SPP
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