Gynecologic and Obstetric Investigation
Original Paper
Diagnostic Reliability of Simultaneous Measurements of Beta Human Chorionic Gonadotropin and Pregnancy-Specific Beta-1-Glycoprotein in Serum of Patients with Trophoblastic DiseaseTakayama M. · Soma H. · Isaka K. · Okudera K. · Ogawa T. · Kikuchi K.Department of Obstetrics and Gynecology, Tokyo Medical College Hospital, Nishi-Shinjuku, Shinjuku-ku, Tokyo, Japan
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Article / Publication Details
Received: January 01, 1986
Accepted: February 14, 1986
Published online: March 15, 2010
Issue release date: 1987
Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 0
ISSN: 0378-7346 (Print)
eISSN: 1423-002X (Online)
For additional information: https://www.karger.com/GOI
Abstract
Serum levels for Β-human chorionic gonadotropin (Β-hCG) and pregnancy-specific Β1-glycoprotein (SP1) in patients with trophoblastic disease were measured by radioimmunoassay and enzyme-linked immunosorbent assay. The Β-hCG:SP1 ratios were below 1.0 in all 22 cases of complete hydatidiform mole and in 8 of 9 cases of partial hydatidiform mole. Two (10.5%) of 19 cases of invasive mole involving metastasis had ratios that rose above 1.0 during chemotherapy. Ratios ranged from 1.6 to 29 in 11 of 15 cases of choriocarcinoma before chemotherapy. The remaining 4 cases, diagnosed within 3 months of antecedent pregnancy, had ratios below 0.99. Thus, the difference between choriocarcinoma and nonchoriocarcinoma Β-hCG:SP1 ratios may be due to trophoblastic differentiation based on the developmental stage and with trophoblast age, or due to the mass and potential activity of trophoblastic cells.
© 1987 S. Karger AG, Basel
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Article / Publication Details
Received: January 01, 1986
Accepted: February 14, 1986
Published online: March 15, 2010
Issue release date: 1987
Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 0
ISSN: 0378-7346 (Print)
eISSN: 1423-002X (Online)
For additional information: https://www.karger.com/GOI
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