Gynecologic and Obstetric Investigation
Original Paper
Human Chorionic Gonadotrophin and Pregnancy-Specific Beta-1-Glycoprotein in Predicting Pregnancy Outcome and in Association with Early Pregnancy VomitingKauppila A.a · Heikinheimo M.b · Lohela H.a · Ylikorkala O.aaDepartment of Obstetrics and Gynaecology, University of Oulu, Finland; bDepartment of Bacteriology and Immunology, University of Helsinki, Finland
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Article / Publication Details
Received: October 31, 1983
Accepted: January 25, 1984
Published online: March 15, 2010
Issue release date: 1984
Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 0
ISSN: 0378-7346 (Print)
eISSN: 1423-002X (Online)
For additional information: https://www.karger.com/GOI
Abstract
Serum concentrations of human chorionic gonadotrophin (HCG) and pregnancy specific Β1-glycoprotein (SP1) were measured in 99 women between the 6th and 10th gestational week, before the onset of pregnancy-threatening complications. The markers failed to predict threatening abortion appearing 9–112 days after sampling (n = 11), regardless of whether the pregnancy continued (n = 2) or ended with abortion (n = 9). Normal HCG and SP1 values were observed in 4 women who subsequently had preterm delivery. 14 women with daily vomiting had higher mean serum concentrations of HCG (p < 0.01) and SP1 (p < 0.05) than 12 women of the same gestational duration without nausea or vomiting. Our results thus show that random single HCG or SP1 determinations have minimal clinical value in predicting the failure of pregnancy and that early pregnancy vomiting seems to be associated with raised serum HCG and SP1 concentrations.
© 1984 S. Karger AG, Basel
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Article / Publication Details
Received: October 31, 1983
Accepted: January 25, 1984
Published online: March 15, 2010
Issue release date: 1984
Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 0
ISSN: 0378-7346 (Print)
eISSN: 1423-002X (Online)
For additional information: https://www.karger.com/GOI
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