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Original Research Article

Broad Spectrum Herbal Therapy against Superficial Fungal Infections

Shahi S.K.a · Shukla A.C.a · Bajaj A.K.b · Banerjee U.c · Rimek D.d · Midgely G.e · Dikshit A.a

Author affiliations

aBotany Department, University of Allahabad, India; bDepartment of Dermatology, Moti Lal Nehru Medical College, Allahabad, India; cDepartment of Microbiology, All India Institute of Medical Sciences, New Delhi, India, dHygiene Institute, Heidelberg, Germany, and eSt. John’s Institute of Dermatology, St. Thomas Hospital, London, UK

Related Articles for ""

Skin Pharmacol Appl Skin Physiol 2000;13:60–64

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Article / Publication Details

First-Page Preview
Abstract of Original Research Article

Published online: February 12, 2000
Issue release date: January – February

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 2

ISSN: 1660-5527 (Print)
eISSN: 1660-5535 (Online)

For additional information: http://www.karger.com/SPP

Abstract

Skin disease associated with keratinized tissues in animal and human beings has been investigated. The essential oil of Eucalyptus pauciflora in vitro showed strong antifungal activity at 1.0 μl/ml against human pathogenic fungi, viz. Epidermophyton floccosum, Microsporum audouinii, M. canis, M. gypseum, M. nanum, Trichophyton mentagrophytes, T. rubrum, T. tonsurans and T. violaceum. The oil has heavy doses of inoculum potential at 1.0 μl/ml. Moreover, it did not exhibit any adverse effects on mammalian skin up to 5% concentrations. Further, we formulated the oil in the form of ointment ‘BSHT’ (broad spectrum herbal therapy) (1% v/v) and subjected it to topical testing on patients attending the outpatient department of M.L.N. Medical College, Allahabad. Fifty patients were selected on the basis of KOH-positive results and diagnosed as either tinea pedis, tinea corporis or tinea cruris. After the second week of treatment, all patients were KOH-negative. At the end of medication, 60% of patients recovered completely and 40% showed significant improvement from the disease. No KOH-negative cases of relapse were observed when patients were re-examined after 2 months following the end of treatment. Thus, the ointment can be exploited commercially after undergoing successful multicenter clinical trials, which are in progress.

© 2000 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Research Article

Published online: February 12, 2000
Issue release date: January – February

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 2

ISSN: 1660-5527 (Print)
eISSN: 1660-5535 (Online)

For additional information: http://www.karger.com/SPP


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