Gynecologic and Obstetric Investigation
Original Paper
Circulating Levels of Placental Protein 5 in Normal and Abnormal PregnanciesTakayama M. · Soma H. · Saito T. · Isaka K. · Kashiwagi H. · Ogawa T. · Suzuki Y. · Sayama S.Department of Obstetrics and Gynecology, Tokyo Medical College Hospital, Tokyo, Japan
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Article / Publication Details
Received: November 08, 1982
Accepted: February 25, 1983
Published online: March 16, 2010
Issue release date: 1983
Number of Print Pages: 14
Number of Figures: 0
Number of Tables: 0
ISSN: 0378-7346 (Print)
eISSN: 1423-002X (Online)
For additional information: https://www.karger.com/GOI
Abstract
Serum concentrations of PP5 were measured by radioimmunoassay in 219 women with normal pregnancies and 163 women whose pregnancies were complicated. PP5 in serum disappeared rapidly after delivery, with a half-life of 5–10 min in the first 10min. Serum PP5 levels were higher in uterine than in antecubital venous blood. In normal pregnancies, PP5 was detectable at 7–8 weeks of gestation; its mean concentration rose gradually to a maximum of 17.8 ± 10.2 ng/ml at 34–35 weeks of gestation. Elevated serum PP5 concentrations were noted in patients whose pregnancies were complicated by toxemia of pregnancy with appropriate-for-date baby or by twin pregnancy. Low serum PP5 concentrations tended to be found in patients whose pregnancies were complicated by abortion, intrauterine fetal death, and hydatidiform mole. Marked abnormal PP5 levels were not found in patients with maternal diabetes and placenta previa. These findings suggest that the assay of serum PP5 concentrations can be a useful parameter in determining the prognosis of abnormal pregnancies.
© 1983 S. Karger AG, Basel
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Article / Publication Details
Received: November 08, 1982
Accepted: February 25, 1983
Published online: March 16, 2010
Issue release date: 1983
Number of Print Pages: 14
Number of Figures: 0
Number of Tables: 0
ISSN: 0378-7346 (Print)
eISSN: 1423-002X (Online)
For additional information: https://www.karger.com/GOI
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