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Review

Histamine Receptors on Lymphocytes: Distribution and Functional Significance

Sachs B. · Hertl M. · Merk H.F.

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Department of Dermatology and Allergology, University Hospitals, Rheinisch-Westfälische Technische Hochschule Aachen, Germany

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Skin Pharmacol Appl Skin Physiol 2000;13:313–323

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Article / Publication Details

First-Page Preview
Abstract of Review

Published online: November 17, 2000
Issue release date: November – December

Number of Print Pages: 11
Number of Figures: 0
Number of Tables: 0

ISSN: 1660-5527 (Print)
eISSN: 1660-5535 (Online)

For additional information: https://www.karger.com/SPP

Abstract

Several investigations reported modulation of lymphocyte functions following activation of the histamine H2 receptor. However, few data have accumulated with regard to the distribution of histamine H2 receptors on different lymphocyte subsets. Conversely, the distribution of histamine H1 receptors on different lymphocyte subsets has been thoroughly analyzed using specific radioligands, whereas the functional significance of histamine H1 receptor ligation on lymphocytes has not been fully elucidated yet. Recent investigations suggest that H1R signaling on lymphocytes may enhance whereas activation of the H2R may inhibit lymphocyte responses. In this review, the authors discuss the current knowledge on distribution and functional significance of histamine H1 and histamine H2 receptors on human lymphocytes.

© 2000 S. Karger AG, Basel


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Article / Publication Details

First-Page Preview
Abstract of Review

Published online: November 17, 2000
Issue release date: November – December

Number of Print Pages: 11
Number of Figures: 0
Number of Tables: 0

ISSN: 1660-5527 (Print)
eISSN: 1660-5535 (Online)

For additional information: https://www.karger.com/SPP


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