Gynecologic and Obstetric Investigation
Original Paper
Fenoterol-Induced Changes of Urine Excretion, Body Weight, Blood Hematocrit, Hemoglobin, Total Protein Values and Serum Electrolyte Levels in Pregnant RabbitsFenske M.a · Grospietsch G.b · Dietrich B.b · Ensinkh F.B.M.b · Hölzl M.b · Kuhn W.baLehrstuhl für Tierphysiologie, Universität Bayreuth, BRD; bAbteilung für Geburtshilfe und Gynäkologie, Universitäts-Frauenklinik Göttingen, BRD
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Article / Publication Details
Received: September 09, 1981
Accepted: December 15, 1981
Published online: March 16, 2010
Issue release date: 1982
Number of Print Pages: 10
Number of Figures: 0
Number of Tables: 0
ISSN: 0378-7346 (Print)
eISSN: 1423-002X (Online)
For additional information: https://www.karger.com/GOI
Abstract
Infusion of the Β2-sympathomimetic agonist fenoterol into pregnant rabbits at a dose of 20 µg/kg/min + 2.5 or 30 ml/h isotonic solution significantly reduced urine excretion. Body weight changes of animals infused with 20 µg/kg/min fenoterol + 2.5 or 30 ml/h isotonic solution were inversely correlated to the reduction of urine excretion. The urinary potassium excretion per 24 h was not significantly altered after the infusion of fenoterol + 2.5 or 30 ml/h isotonic solution. On the other hand, the urinary sodium excretion per 24 h was significantly decreased in animals infused with 20 µg/kg/min fenoterol + 30 ml/h isotonic solution. Infusion of 20 µg/kg/min fenoterol + 2.5 ml/h isotonic solution did not significantly change hematocrit, hemoglobin or total protein values. In contrast, increasing the volume of isotonic solution to 30 ml/h resulted in significantly decreased hematocrit, hemoglobin and total protein levels at 6, 12 and 24 h after starting infusion. Serum potassium concentrations were reduced at 2–24 h after infusion of 20 µg/kg/min fenoterol + 2.5 or 30 ml/h isotonic solution was started. The serum sodium concentrations did not change significantly during the infusion of 20 µg/kg/min fenoterol + 2.5 or 30 ml/h isotonic solution. While in animals infused with isotonic solution alone or with 20 µg/kg/min fenoterol + 2.5 ml/h isotonic solution the central venous pressure did not change significantly, it was strongly increased in animals infused with 20 µg/kg/min fenoterol + 30 ml/h isotonic solution at 12–24 h after start of infusion. The results of this study are discussed with respect to those obtained from pregnant women under tocolytic therapy and to the possible pathomechanism of the development of pulmonary edema.
© 1982 S. Karger AG, Basel
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Article / Publication Details
Received: September 09, 1981
Accepted: December 15, 1981
Published online: March 16, 2010
Issue release date: 1982
Number of Print Pages: 10
Number of Figures: 0
Number of Tables: 0
ISSN: 0378-7346 (Print)
eISSN: 1423-002X (Online)
For additional information: https://www.karger.com/GOI
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Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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