Gynecologic and Obstetric Investigation
Original Paper
Opioid Plasma Levels during LabourFacchinetti F.a · Centini G.a · Parrini D.a · Petraglia F.a · D’;Antona N.b · Cosmi E.V.c · Genazzani A.R.daClinica Ostetrica e Ginecologica, Università di Siena; bCattedra di Patologia Ostetrica e Ginecologica, Università di Messina; c2a Cattedra di Clinica Ostetrica e Ginecologica, Università di Perugia; dCattedra di Patologia Ostetrica e Ginecologica, Università di Cagliari, Italia
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Article / Publication Details
Received: February 10, 1981
Accepted: April 27, 1981
Published online: March 16, 2010
Issue release date: 1982
Number of Print Pages: 9
Number of Figures: 0
Number of Tables: 0
ISSN: 0378-7346 (Print)
eISSN: 1423-002X (Online)
For additional information: https://www.karger.com/GOI
Abstract
6 healthy pregnant women, monitored with external cardiotocography, were studied. Blood samples were collected hourly throughout labour until delivery of the fetus and placenta, and again on the 5th day of puerperium. Β -Lipotropin (ΒLPH) and Β-endorphin (ΒEP) were determined by specific radioimmunoassays in each sample, after silicic acid plasma extraction and G-75 column chromatography. Both opioid plasma levels rise progressively during labour, reaching their highest values 1 h before delivery (ΒLPH: 296.0 ± 60.2 pg/ml; ΒEP: 106.2 ± 40.6 pg/ml) as compared with values of 157.0 ± 35.4 (ΒLPH) and 57.0 ± 7.3 pg/ml (ΒEP) (mean ± SE) at the beginning of labour. With the exception of 1 case, a significant correlation was observed between ΒLPH and Β ΒEP plasma levels. The two opioid plasma levels decrease after delivery (195.3 ± 47.1 and 88.3 ± 39.7 pg/ml, respectively), but increase again after delivery of the placenta (272.5 ± 59.6 and 118.2 ± 68.4 pg/ml) and subsequently decrease further to levels of 105.6 ± 46.4 (ΒLPH) and 33.7 ± 16.5 (ΒEP) on the 5th day of puerperium. ΒLPH and ΒEP plasma levels showed a significant correlation throughout labour with the ‘uterine contractility force/hour’, which was calculated by the addition of tocographic areas of each uterine contraction at 1 -hour intervals. These data demonstrate that the increase in plasma opioid concentrations during labor is directly related to the number and intensity of uterine contractions.
© 1982 S. Karger AG, Basel
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Article / Publication Details
Received: February 10, 1981
Accepted: April 27, 1981
Published online: March 16, 2010
Issue release date: 1982
Number of Print Pages: 9
Number of Figures: 0
Number of Tables: 0
ISSN: 0378-7346 (Print)
eISSN: 1423-002X (Online)
For additional information: https://www.karger.com/GOI
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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