Gynäkologisch-geburtshilfliche Rundschau
Schwerpunkt: Gestationsdiabetes
Fetoplazentare Störungen bei GestationsdiabetesHiden U. · Lang U. · Desoye G.Universitätsklinik für Frauenheilkunde und Geburtshilfe, Medizinische Universität Graz, Graz, Österreich
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Gynäkol Geburtshilfliche Rundsch 2009;49:224–229
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Article / Publication Details
First-Page Preview
Published online: May 19, 2010
Issue release date: May 2010
Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 1
ISSN: 1018-8843 (Print)
eISSN: 1423-0011 (Online)
For additional information: https://www.karger.com/GGR
Abstract
Die Plazenta an der Schnittstelle zwischen Mutter und Fetus ist mütterlichen und fetalen Einflüssen ausgesetzt. Insbesondere Insulin und die insulinähnlichen Wachstumsfaktoren der Typen 1 und 2 (IGF1 und IGF2) regulieren Wachstum und Funktion der Plazenta. Gestationsdiabetes ist assoziiert mit hormonellen und metabolischen Veränderungen in beiden Blutkreisläufen. Auch die Konzentrationen von Insulin, IGF1 und IGF2 sind bei Gestationsdiabetes verändert, was sich auf Plazenta und Kind auswirken kann. In diesem Artikel werden die Veränderungen der Plazenta bei Gestationsdiabetes beschrieben und die Rolle, die Insulin, IGF1 und IGF2 darin spielen, diskutiert.
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Literatur
- Fee BA, Weil WB Jr: Body composition of infants of diabetic mothers by direct analysis. Ann NY Acad Sci 1963;110:869–897.
- Durnwald C, et al: Evaluation of body composition of large-for-gestational-age infants of women with gestational diabetes mellitus compared with women with normal glucose tolerance levels. Am J Obstet Gynecol 2004;191:804–808.
- Desoye G, Hofmann HH, Weiss PA: Insulin binding to trophoblast plasma membranes and placental glycogen content in well-controlled gestational diabetic women treated with diet or insulin, in well-controlled overt diabetic patients and in healthy control subjects. Diabetologia 1992;35:45–55.
- Osmond DT, et al: Placental glucose transport and utilisation is altered at term in insulin-treated, gestational-diabetic patients. Diabetologia 2001;44:1133–1139.
- Osmond DT, et al: Effects of gestational diabetes on human placental glucose uptake, transfer, and utilisation. Diabetologia 2000;43:576–582.
- Jansson T, et al: Alterations in the activity of placental amino acid transporters in pregnancies complicated by diabetes. Diabetes 2002;51:2214–2219.
- Dicke JM, Henderson GI: Placental amino acid uptake in normal and complicated pregnancies. Am J Med Sci 1988;295:223–227.
- Kuruvilla AG, et al: Altered activity of the system A amino acid transporter in microvillous membrane vesicles from placentas of macrosomic babies born to diabetic women. J Clin Invest 1994;94:689–695.
- Thomas B, et al: Plasma AA and DHA levels are not compromised in newly diagnosed gestational diabetic women. Eur J Clin Nutr 2004;58:1492–1497.
- Ortega-Senovilla H, et al: Gestational diabetes mellitus upsets the proportion of fatty acids in umbilical arterial but not venous plasma. Diabetes Care 2009;32:120–122.
- Bitsanis D, et al: Gestational diabetes mellitus enhances arachidonic and docosahexaenoic acids in placental phospholipids. Lipids 2006;41:341–346.
- Merzouk H, et al: Changes in serum lipid and lipoprotein concentrations and compositions at birth and after 1 month of life in macrosomic infants of insulin-dependent diabetic mothers. Eur J Pediatr 1999;158:750–756.
- Couch SC, et al: Elevated lipoprotein lipids and gestational hormones in women with diet-treated gestational diabetes mellitus compared to healthy pregnant controls. J Diabetes Complications 1998;12:1–9.
- al-Okail MS, al-Attas OS: Histological changes in placental syncytiotrophoblasts of poorly controlled gestational diabetic patients. Endocr J 1994;41:355–360.
- Leushner JR, et al: Analysis of the collagens of diabetic placental villi. Cell Mol Biol 1986;32:27–35.
- Madsen H, Ditzel J: Red cell 2,3-diphosphoglycerate and hemoglobin-oxygen affinity during diabetic pregnancy. Acta Obstet Gynecol Scand 1984;63:403–406.
- Madazli R, et al: The incidence of placental abnormalities, maternal and cord plasma malondialdehyde and vascular endothelial growth factor levels in women with gestational diabetes mellitus and nondiabetic controls. Gynecol Obstet Invest 2008;65:227–232.
- Mayhew TM, et al: Growth and maturation of villi in placentae from well-controlled diabetic women. Placenta 1994;15:57–65.
- Black SM, Devol JM, Wedgwood S: Regulation of fibroblast growth factor-2 expression in pulmonary arterial smooth muscle cells involves increased reactive oxygen species generation. Am J Physiol Cell Physiol 2008;294:C345–C354.
-
Josko J, Mazurek M: Transcription factors having impact on vascular endothelial growth factor (VEGF) gene expression in angiogenesis. Med Sci Monit 2004;10:RA89–RA98.
- Jirkovska M, et al: Topological properties and spatial organization of villous capillaries in normal and diabetic placentas. J Vasc Res 2002;39:268–278.
- Iioka H, et al: Nonenzymatic glucosylation of human placental trophoblast basement membrane collagen (relation to diabetic placenta pathology) (auf Japanisch). Nippon Sanka Fujinka Gakkai Zasshi 1987;39:400–404.
- Hauguel-de Mouzon S, Louizeau M, Girard J: Functional alterations of type I insulin-like growth factor receptor in placenta of diabetic rats. Biochem J 1992;288:273–279.
- Persson A, et al: Na+/K+-ATPase activity and expression in syncytiotrophoblast plasma membranes in pregnancies complicated by diabetes. Placenta 2002;23:386–391.
- Gaither K, Quraishi AN, Illsley NP: Diabetes alters the expression and activity of the human placental GLUT1 glucose transporter. J Clin Endocrinol Metab 1999;84:695–701.
- Schonfelder G, et al: Expression of inducible nitric oxide synthase in placenta of women with gestational diabetes. FASEB J 1996;10:777–784.
- Lea RG, et al: Placental leptin in normal, diabetic and fetal growth-retarded pregnancies. Mol Hum Reprod 2000;6:763–769.
- Burleigh DW, et al: Influence of maternal diabetes on placental fibroblast growth factor-2 expression, proliferation, and apoptosis. J Soc Gynecol Investig 2004;11:36–41.
- Yang WC, et al: Altered perlecan expression in placental development and gestational diabetes mellitus. Placenta 2005;26:780–788.
- Babawale MO, et al: Effects of gestational diabetes on junctional adhesion molecules in human term placental vasculature. Diabetologia 2000;43:1185–1196.
- Magnusson AL, et al: Triglyceride hydrolase activities and expression of fatty acid binding proteins in the human placenta in pregnancies complicated by intrauterine growth restriction and diabetes. J Clin Endocrinol Metab 2004;89:4607–4614.
- Alonso A, et al: Effects of gestational diabetes mellitus on proteins implicated in insulin signaling in human placenta. Gynecol Endocrinol 2006;22:526–535.
- Bhaumick B, Danilkewich AD, Bala RM: Altered placental insulin and insulin-like growth factor-I receptors in diabetes. Life Sci 1988;42:1603–1614.
- Radaelli T, et al: Gestational diabetes induces placental genes for chronic stress and inflammatory pathways. Diabetes 2003;52:2951–2958.
- Gicquel C, Le Bouc Y: Hormonal regulation of fetal growth. Horm Res 2006;65(suppl 3):28–33.
- Desoye G, et al: Location of insulin receptors in the placenta and its progenitor tissues. Microsc Res Tech 1997;38:63–75.
- Hiden U, et al: Insulin control of placental gene expression shifts from mother to foetus over the course of pregnancy. Diabetologia 2006;49:123–131.
- Susa JB, et al: Chronic hyperinsulinemia in the fetal rhesus monkey: effects of physiologic hyperinsulinemia on fetal growth and composition. Diabetes 1984;33:656–660.
- Godfrey KM, et al: Relation of cord plasma concentrations of proinsulin, 32–33 split proinsulin, insulin and C-peptide to placental weight and the baby’s size and proportions at birth. Early Hum Dev 1996;46:129–140.
- Shields BM, et al: Mutations in the glucokinase gene of the fetus result in reduced placental weight. Diabetes Care 2008;31:753–757.
- Lemons JA, Ridenour R, Orsini EN: Congenital absence of the pancreas and intrauterine growth retardation. Pediatrics 1979;64:255–257.
-
Kaufmann P, Luckhardt M, Leiser R: Three-dimensional representation of the fetal vessel system in the human placenta. Trophoblast Res 1988;3:113–117.
- Mayhew TM: Fetoplacental angiogenesis during gestation is biphasic, longitudinal and occurs by proliferation and remodelling of vascular endothelial cells. Placenta 2002;23:742–750.
- Hiden U, et al: Insulin and the IGF system in the human placenta of normal and diabetic pregnancies. J Anat 2009;215:60–68.
- Westgate JA, et al: Hyperinsulinemia in cord blood in mothers with type 2 diabetes and gestational diabetes mellitus in New Zealand. Diabetes Care 2006;29:1345–1350.
- Treins C, et al: Insulin stimulates hypoxia-inducible factor 1 through a phosphatidylinositol 3-kinase/target of rapamycin-dependent signaling pathway. J Biol Chem 2002;277:27975–27981.
- Lang I, et al: Human fetal placental endothelial cells have a mature arterial and a juvenile venous phenotype with adipogenic and osteogenic differentiation potential. Differentiation 2008;76:1031–1043.
-
Lucas J, et al: The effect of fetal hyperinsulinemia on human placental vascular function: perfusion of fetal microvascular bed with high insulin results in increased vascular leakage and loss of junctional beta-catenin. Microcirculation, im Druck.
- Leach L, et al: Vascular endothelial cadherin and beta-catenin in human fetoplacental vessels of pregnancies complicated by type 1 diabetes: associations with angiogenesis and perturbed barrier function. Diabetologia 2004;47:695–709.
- Schmon B, et al: Insulin and glucose do not affect the glycogen content in isolated and cultured trophoblast cells of human term placenta. J Clin Endocrinol Metab 1991;73:888–893.
- Desoye G, Hauguel-de Mouzon S: The human placenta in gestational diabetes mellitus: the insulin and cytokine network. Diabetes Care 2007;30(suppl 2):S120–S126.
- Jones CJ, Desoye G: Glycogen distribution in the capillaries of the placental villus in normal, overt and gestational diabetic pregnancy. Placenta 1993;14:505–517.
- Hayati AR, et al: Insulin-like growth factor-1 receptor expression in the placentae of diabetic and normal pregnancies. Early Hum Dev 2007;83:41–46.
- Guyda HJ: Metabolic effects of growth factors and polycyclic aromatic hydrocarbons on cultured human placental cells of early and late gestation. J Clin Endocrinol Metab 1991;72:718–723.
- Karl PI: Insulin-like growth factor-1 stimulates amino acid uptake by the cultured human placental trophoblast. J Cell Physiol 1995;165:83–88.
- Bloxam DL, Bax BE, Bax CM: Epidermal growth factor and insulin-like growth factor I differently influence the directional accumulation and transfer of 2-aminoisobutyrate (AIB) by human placental trophoblast in two-sided culture. Biochem Biophys Res Commun 1994;199:922–929.
- Cetin I, et al: Maternal and fetal amino acid concentrations in normal pregnancies and in pregnancies with gestational diabetes mellitus. Am J Obstet Gynecol 2005;192:610–617.
- Abuzzahab MJ, et al: IGF-I receptor mutations resulting in intrauterine and postnatal growth retardation. N Engl J Med 2003;349:2211–2222.
- Okubo Y, et al: Cell proliferation activities on skin fibroblasts from a short child with absence of one copy of the type 1 insulin-like growth factor receptor (IGF1R) gene and a tall child with three copies of the IGF1R gene. J Clin Endocrinol Metab 2003;88:5981–5988.
- Takayama S, et al: Reproductive toxicity of ofloxacin. Arzneimittelforschung 1986;36:1244–1248.
- Shapiro LR, et al: The placenta in familial Beckwith-Wiedemann syndrome. Birth Defects Orig Artic Ser 1982;18:203–206.
- Hughes SC, et al: Could abnormalities in insulin-like growth factors and their binding proteins during pregnancy result in gestational diabetes? J Endocrinol 1995;147:517–524.
- Gelato MC, et al: The serum insulin-like growth factor-II/mannose-6-phosphate receptor in normal and diabetic pregnancy. Metabolism 1993;42:1031–1038.
- Lindsay RS, et al: Inverse changes in fetal insulin-like growth factor (IGF)-1 and IGF binding protein-1 in association with higher birth weight in maternal diabetes. Clin Endocrinol (Oxf) 2007;66:322–328.
- Roth S, et al: Insulin-like growth factors I and II peptide and messenger RNA levels in macrosomic infants of diabetic pregnancies. J Soc Gynecol Investig 1996;3:78–84.
Article / Publication Details
First-Page Preview
Published online: May 19, 2010
Issue release date: May 2010
Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 1
ISSN: 1018-8843 (Print)
eISSN: 1423-0011 (Online)
For additional information: https://www.karger.com/GGR
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