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Metabolic Clearance Rate and Production Rate of 20α-Hydroxypregn-4-en-3-one in the Menstrual Cycle

Billiar R.B. · Lin T.J. · Little B.

Author affiliations

The Department of Reproductive Biology, Case Western Reserve University School of Medicine, and Department of Obstetrics and Gynecology, Cleveland Metropolitan General Hospital, Cleveland, Ohio

Related Articles for ""

Gynecol. Invest. 1973;4:148–154

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Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: March 18, 2010
Issue release date: 1973

Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 0

ISSN: 0378-7346 (Print)
eISSN: 1423-002X (Online)

For additional information: https://www.karger.com/GOI

Abstract

The metabolic clearance rate (MCRrB), plasma concentration, and production rate (PI) and conversion to progesterone of 20Α-hydroxypregn-4-en-3-one (20Α-OHP) have been determined in women during the menstrual cycle. The MCRrB was 3,110 ± 217 (SE) 1/day and was independent of the day of the cycle. The PI was 0.92–2.53 mg/day for days 6–18 of the cycle and 0.78–15.6 mg/day for days 20–24. The percent conversion of 20Α-OHP to progesterone was 4.88 ± 1.10 (SE)% and the calculated transfer constant of 20Α-OHP to progesterone was 0.05. The contribution of progesterone to the blood production rate of 20Α-OHP for days 20–24 was calculated to be between 24 and 73 %, and it was concluded that plasma concentrations of 20Α-OHP are not a valid indicator of corpus luteum regression in the human.

© 1973 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: March 18, 2010
Issue release date: 1973

Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 0

ISSN: 0378-7346 (Print)
eISSN: 1423-002X (Online)

For additional information: https://www.karger.com/GOI


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