Hormone Research in Paediatrics

Original Paper

Expression and Protein Content of IGF-I and IGF-I Receptor in Placentas from Small, Adequate and Large for Gestational Age Newborns

Iñiguez G. · González C.A. · Argandoña F. · Kakarieka E. · Johnson M.C. · Cassorla F.

Author affiliations

Institute of Maternal and Child Research, and Hospital Clínico San Borja-Arriarán, University of Chile, Santiago, Chile

Keywords: IGF-IIGF-I receptorPlacentaBirth weightSmall for gestational age

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Horm Res Paediatr 2010;73:320–327
https://doi.org/10.1159/000308163

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: March 16, 2009
Accepted: June 20, 2009
Published online: April 14, 2010
Issue release date: April 2010

Number of Print Pages: 8
Number of Figures: 2
Number of Tables: 2

ISSN: 1663-2818 (Print)
eISSN: 1663-2826 (Online)

For additional information: https://www.karger.com/HRP

Abstract

In humans, a direct relationship between IGF-I cord blood levels and birth weight has been demonstrated. To determine the placental IGF-I, IGF-II and IGF-IR mRNA and protein contents in full-term pregnancies from appropriate for gestational age (AGA), small for gestational age (SGA) and large for gestational age (LGA) newborns, we studied the placentas from 35 AGA, 30 SGA and 28 LGA pregnancies. The IGF-I, IGF-II and IGF-I receptor (IGF-IR) placental mRNA and protein contents were determined in the basal and chorionic plates of the placenta. IGF1 and IGF1R mRNA was higher in SGA compared to AGA and LGA placentas and lower in LGA compared with AGA placentas. In addition, a higher protein content of IGF-I and IGF-IR was observed in SGA compared with AGA and LGA placentas and lower contents in LGA compared with AGA placentas. These results suggest that the higher IGF-I and IGF-IR contents observed in SGA placentas and the lower contents observed in LGA placentas compared with AGA placentas may be influencing human fetal growth.

© 2010 S. Karger AG, Basel



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References

  1. Resnik R: Intrauterine growth restriction. Obstet Gynecol 2002;99:490–496.
    External Resources
  2. Low JA, Handley-Derry MH, Burke SO, Peters RD, Pater EA, Killen HL, Derrick EJ: Association of intrauterine fetal growth retardation and learning deficits at age 9 to 11 years. Am J Obstet Gynecol 1992;167:1499–1505.
    External Resources
  3. Kramer MS, Olivier M, McLean FH, Willis DM, Usher RH: Impact of intrauterine growth retardation and body proportionality on fetal and neonatal outcome. Pediatrics 1990;86:707–713.
    External Resources
  4. Hattersley AT, Tooke JE: The fetal insulin hypothesis: an alternative explanation of the association of low birth weight with diabetes and vascular disease. Lancet 1999;353:1789–1792.
    External Resources
  5. Barker DJ: The developmental origins of well-being. Philos Trans R Soc Lond B Biol Sci 2004;359:1359–1366.
    External Resources
  6. DeChiara TM, Efstratiadis A, Robertson EJ: A growth-deficiency phenotype in heterozygous mice carrying an insulin-like growth factor II gene disrupted by targeting. Nature 1990;345:78–80.
    External Resources
  7. Baker J, Liu JP, Robertson EJ, Efstratiadis A: Role of insulin-like growth factors in embryonic and postnatal growth. Cell 1993;75:73–82.
    External Resources
  8. Liu JP, Baker J, Perkins AS, Robertson EJ, Efstratiadis A: Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r). Cell 1993;75:59–72.
    External Resources
  9. Fowden AL: The insulin-like growth factors and feto-placental growth. Placenta 2003;24:803–812.
    External Resources
  10. Han VK, Carter AM: Spatial and temporal patterns of expression of messenger RNA for insulin-like growth factors and their binding proteins in the placenta of man and laboratory animals. Placenta 2000;21:289–305.
    External Resources
  11. Abuzzahab MJ, Schneider A, Goddard A, Grigorescu F, Lautier C, Keller E, Kiess W, Klammt J, Kratzsch J, Osgood D: IGF-I receptor mutations resulting in intrauterine and postnatal growth retardation. N Engl J Med 2004;349:2211–2222.
    External Resources
  12. Walenkamp MJE, van der Kamp HJ, Pereira AM, Kant SG, van Duyvenvoorde HA, Kruithof MF, Breuning MH, Romijn JA, Karperien M, Wit JM: A variable degree of intrauterine and postnatal growth retardation in a family with a missense mutation in the insulin-like growth factor I receptor. J Clin Endocrinol Metab 2006;91:3062–3070.
    External Resources
  13. Arends N, Johnston LB, Hokken-Koelega A, Van Duin C, De Ridder M, Savage M, Clark A: Polymorphism in the IGF-I gene: clinical relevance for short children born small for gestational age (SGA). J Clin Endocrinol Metab 2002;87:2720–2724.
    External Resources
  14. Woods KA, Camacho-Hübner C, Savage MO, Clark AJ: Intrauterine growth retardation and postnatal growth failure associated with deletion of the insulin-like growth factor I gene. N Engl J Med 1996;335:1389–1391.
    External Resources
  15. Walenkamp MJ, Karperien M, Pereira AM, Hilhorst-Hofstee Y, van Doorn J, Chen JW, Mohan S, Denley A, Forbes B, van Duyvenvoorde HA, van Thiel SW, Sluimers CA, Bax JJ, de Laat JA, Breuning MB, Romijn JA, Wit JM: Homozygous and heterozygous expression of a novel insulin-like growth factor-I mutation. J Clin Endocrinol Metab 2005;90:2855–2864.
    External Resources
  16. Eggenschwiler J, Ludwig T, Fisher P, Leighton PA, Tilghman SM, Efstratiadis A: Mouse mutant embryos overexpressing IGF-II exhibit phenotypic features of the Beckwith-Wiedemann and Simpson-Golabi-Behmel syndromes. Genes Dev 1997;11:3128–3142.
    External Resources
  17. Davidson S, Hod M, Merlob P, Shtaif B: Leptin, insulin, insulin-like growth factors and their binding proteins in cord serum: insight into fetal growth and discordancy. Clin Endocrinol (Oxf) 2006;65:586–592.
    External Resources
  18. Abu-Amero SN, Ali Z, Bennett P, Vaughan JI, Moore GE: Expression of the insulin-like growth factors and their receptors in term placentas: a comparison between normal and IUGR births. Mol Reprod Dev 1998;49:229–235.
    External Resources
  19. Street ME, Seghini P, Fieni S, Ziveri MA, Volta C, Martorana D, Viani I, Gramellini D, Bernasconi S: Changes in interleukin-6 and IGF system and their relationships in placenta and cord blood in newborns with fetal growth restriction compared with controls. Eur J Endocrinol 2006;155:567–574.
    External Resources
  20. Dalçik H, Yardimoğlu M, Vural B, Dalçik C, Filiz S, Gonca S, Köktürk S, Ceylan S: Expression of insulin-like growth factor in the placenta of intrauterine growth-retarded human fetuses. Acta Histochem 2001;103:195–207.
    External Resources
  21. Calvo MT, Romo A, Gutiérrez JJ, Relaño E, Barrio E, Ferrández Longás A: Study of genetic expression of intrauterine growth factors IGF-I and EGFR in placental tissue from pregnancies with intrauterine growth retardation J Pediatr Endocrinol Metab 2004;17(suppl 3):445–450.
  22. Juez G, Lucero E, Ventura-Juncá P, Tapia J, González H, Winter A: Estudio neonatal del crecimiento intrauterino en 11543 recién nacidos chilenos de clase media 1978–1987. Rev Chil Pediatr 1989;60:198–202.
    External Resources
  23. Wyatt SM, Kraus FT, Roh CR, Elchalal U, Nelson DM, Sadovsky Y: The correlation between sampling site and gene expression in the term human placenta. Placenta 2005;26:372–379.
    External Resources
  24. Johnson MC, Vega M, Vantman D, Troncoso JL, Devoto L: Regulatory role of angiotensin II on progesterone production by cultured human granulosa cells. Expression of angiotensin II type-2 receptor. Mol Hum Reprod 1997;3:663–668.
    External Resources
  25. Schmittgen TD, Zakrajsek BA: Effect of experimental treatment on housekeeping gene expression: validation by real-time, quantitative RT-PCR. J Biochem Biophys Methods 2000;46:69–81.
    External Resources
  26. Iniguez G, Villavicencio A, Gabler F, Palomino A, Vega M: Effect of nitric oxide on the expression of insulin-like growth factors and the insulin-like growth factor binding proteins throughout the lifespan of the human corpus luteum. Reproduction 2001;122:865–873.
    External Resources
  27. Sheikh S, Satoskar P, Bhartiya D: Expression of insulin-like growth factor-I and placental growth hormone mRNA in placentae: a comparison between normal and intrauterine growth retardation pregnancies. Mol Hum Reprod 2001;7:287–292.
    External Resources
  28. Carter AM, Kingston MJ, Han KK, Mazzuca DM, Nygard K, Han VK: Altered expression of IGFs and IGF-binding proteins during intrauterine growth restriction in guinea pigs. J Endocrinol 2005;184:179–189.
    External Resources
  29. Trollmann R, Klingmüller K, Schild RL, Rascher W, Dötsch J: Differential gene expression of somatotrophic and growth factors in response to in vivo hypoxia in human placenta. Am J Obstet Gynecol 2007;197:601.e1–e6.
    External Resources
  30. Akram SK, Akram M, Bhutta ZA, Soder O: Human placental IGF-I and IGF-II expression: correlating maternal and infant anthropometric variables and micronutrients at birth in the Pakistani population. Acta Paediatr 2008;97:1443–1448.
    External Resources
  31. Ozkan S, Vural B, Dalçik C, Taş A, Dalçik H: Placental expression of insulin-like growth factor-I, fibroblast growth factor-basic and neural cell adhesion molecule in pregnancies with small for gestational age fetuses. J Perinatol 2008;28:468–474.
    External Resources
  32. Davidson S, Hod M, Merlob P, Shtaif B: Leptin, insulin, insulin-like growth factors and their binding proteins in cord serum: insight into fetal growth and discordancy. Clin Endocrinol (Oxf) 2006;65:586–592.
    External Resources
  33. Cianfarani S, Germani D, Rossi P, Rossi L, Germani A, Ossicini C, Zuppa A, Argirò G, Holly JM, Branca F: Intrauterine growth retardation: evidence for the activation of the insulin-like growth factor (IGF)-related growth-promoting machinery and the presence of a cation-independent IGF binding protein-3 proteolytic activity by two months of life. Pediatr Res 1998;44:374–380.
    External Resources
  34. Shin JC, Lee JH, Yang DE, Moon HB, Rha JG, Kim SP: Expression of insulin-like growth factor-II and insulin-like growth factor binding protein-1 in the placental basal plate from pre-eclamptic pregnancies. Int J Gynaecol Obstet 2003;81:273–280.
    External Resources
  35. Leger J, Oury JF, Noel M, Baron S, Benali K, Blot P, Czernichow P: Growth factors and intrauterine growth retardation. I. Serum growth hormone, insulin-like growth factor (IGF)-I, IGF-II, and IGF binding protein 3 levels in normally grown and growth-retarded human fetuses during the second half of gestation. Pediatr Res 1996;40:94–100.
    External Resources
  36. Holmes R, Montemagno R, Jones J, Preece M, Rodeck C, Soothill P: Fetal and maternal plasma insulin-like growth factors and binding proteins in pregnancies with appropriate or retarded fetal growth. Early Hum Dev 1997;49:7–17.
    External Resources
  37. Christou H, Connors JM, Ziotopoulou M, Hatzidakis V, Papathanassoglou E, Ringer SA, Mantzoros CS: Cord blood leptin and insulin-like growth factor levels are independent predictors of fetal growth. J Clin Endocrinol Metab 2001;86:935–938.
    External Resources
  38. Reid GJ, Flozak AS, Simmons RA: Placental expression of insulin-like growth factor receptor-1 and insulin receptor in the growth-restricted fetal rat. J Soc Gynecol Investig 2002;9:210–214.
    External Resources
  39. Gurel D, Ozer E, Altunyurt S, Guclu S, Demir N: Expression of IGR-IR and VEGF and trophoblastic proliferative activity in placentas from pregnancies complicated by IUGR. Pathol Res Pract 2003;199:803–809.
    External Resources
  40. Laviola L, Perrini S, Belsanti G, Natalicchio A, Montrone C, Leonardini A, Vimercati A, Scioscia M, Selvaggi L, Giorgino R, Greco P, Giorgino F: Intrauterine growth restriction in humans is associated with abnormalities in placental insulin-like growth factor signaling. Endocrinology 2005;146:1498–1505.
    External Resources

Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: March 16, 2009
Accepted: June 20, 2009
Published online: April 14, 2010
Issue release date: April 2010

Number of Print Pages: 8
Number of Figures: 2
Number of Tables: 2

ISSN: 1663-2818 (Print)
eISSN: 1663-2826 (Online)

For additional information: https://www.karger.com/HRP

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