Ophthalmologica
Original Paper
Open Noncontrolled Multicenter Long-Term Trial with Ciclosporin in Endogenous Non-Infectious UveitisSecchi A.G.a · De Rosa C.b · Pivetti-Pezzi P.c · Rossi A.d · DeMolfetta V.e · Tognon S.a · Latanza L.b · Catarinelli G.c · Scorrano R.d · Bragliani G.d · Zenoni S.e · Della Casa-Alberighi O.f · Corbetta G.fDepartments of Ophthalmology, Universities of aPadova, cRoma and dFerrara; Departments of Ophthalmology, eOspedale S. Gerardo, Monza, and bOspedale Cardarelli, Napoli; fMedical Department, Sandoz, Italy
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Article / Publication Details
Received: January 14, 1991
Accepted: January 21, 1991
Published online: March 31, 2010
Issue release date: 1991
Number of Print Pages: 8
Number of Figures: 0
Number of Tables: 0
ISSN: 0030-3755 (Print)
eISSN: 1423-0267 (Online)
For additional information: https://www.karger.com/OPH
Abstract
The efficacy, tolerability and safety of low doses (5–7 mg/kg/day) of oral ciclosporin (CS) for treatment of endogenous uveitis resistant to conventional therapy were studied in an open, noncontrolled, multicenter long-term trial. CS was shown to be effective for patients with posterior or intermediate noninfectious uveitis; it limited the progression of the disease, decreased the number and severity of inflammatory relapses, and improved visual acuity while reducing signs of intraocular inflammation. Moreover, in corticodependent patients, a steroid-sparing effect was also obtained. At low doses and by means of the careful monitoring of safety parameters, the side effects (especially renal function impairment) were well controlled. Efficacy was maintained during long-term treatment.
© 1991 S. Karger AG, Basel
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Article / Publication Details
Received: January 14, 1991
Accepted: January 21, 1991
Published online: March 31, 2010
Issue release date: 1991
Number of Print Pages: 8
Number of Figures: 0
Number of Tables: 0
ISSN: 0030-3755 (Print)
eISSN: 1423-0267 (Online)
For additional information: https://www.karger.com/OPH
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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