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Original Paper

Pan–Reactive Platelet Antibodies in Post–Transfusion Purpura

Taaning E.a · Tønnesen F.b

Author affiliations

aDepartment of Clinical Immunology, Glostrup Hospital, and bDepartments of Clinical Immunology and Oncology, Herlev Hospital, University of Copenhagen, Denmark

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Vox Sang 1999;76:120–123

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: March 19, 1999
Issue release date: March 1999

Number of Print Pages: 4
Number of Figures: 1
Number of Tables: 1

ISSN: 0042-9007 (Print)
eISSN: 1423-0410 (Online)

For additional information: https://www.karger.com/VOX

Abstract

Background and Objectives: The mechanism for the destruction of a patient's own platelets in post–transfusion purpura (PTP) is unknown. In order to test the hypothesis that the destruction of autologous platelets in PTP is related to the presence of platelet antibodies with pan–reactivity, we investigated sera from patients with PTP. Materials and Methods: Sera from 12 patients with PTP were investigated for platelet antibodies by platelet–ELISA and monoclonal antibody–specific immobilization of platelet antigen assay. Results: During the thrombocytopenic phase, antibodies of IgG and IgM classes with pan–specificity against platelet GPIIb–IIIa, GPIb–IX and GPIa–IIa were found together with HPA alloantibodies. After recovery, the pan–specific antibodies disappeared or the extent of reactivity diminished, whereas the IgG HPA alloantibodies persisted. Conclusion: These findings provide evidence that transient panreactive antibodies may be responsible for the autologous platelet destruction in PTP.


References

  1. Bierling P, Godeau B, Fromont P, Bettaieb A, Debili N, el Kassar N, Rouby JJ, Vainchenker W, Duedari N: Posttransfusion purpura–like syndrome associated with CD36 (Naka) isoimmunization. Transfusion 1995;35:777–782.
  2. Taaning E: Microplate enzyme immunoassay for detection of platelet antibodies. Tissue Antigens 1985;25:19–27.
  3. Kiefel V, Santoso S, Weisheit M, Mueller Eckhardt C: Monoclonal antibody–specific immobilization of platelet antigens (MAIPA): A new tool for the identification of platelet–reactive antibodies. Blood 1987;70:1722–1726.
  4. Gengozian N, McLaughlin CL: IgG + platelets in the marmoset: Their induction, maintenance and survival. Blood 1980;55:885–890.
    External Resources
  5. Gengozian N, Annostby D: Antibodies selectively reactive to autologous and host–type platelets are obtained following interspecies immunization in marmosets. Clin Exp Immunol 1981;43:128–134.
    External Resources
  6. Pegels JG, Bruynes EC, Engelfriet CP, von dem Borne AE: Post–transfusion purpura: A serological and immunochemical study. Br J Haematol 1981;49:521–530.
    External Resources
  7. Perry RM: The occurrence and significance of platelet and granulocyte specific antibodies in bone marrow transplant patients; PhD thesis. University of London, 1983.
  8. Berney SI, Metcalfe P, Wathen NC, Waters AH: Posttransfusion purpura responding to high dose intravenous IgG: Further observations on pathogenesis. Br J Haematol 1985;61: 627–632.
    External Resources
  9. Stricker RB, Lewis BH, Corash L, Shuman MA: Posttransfusion purpura associated with an autoantibody directed against a previously undefined platelet antigen. Blood 1987;69: 1458–1463.
    External Resources
  10. Minchinton RM, Cunningham I, Cole Sinclair M, Van der Weyden M, Vaughan S, McGrath KM: Autoreactive platelet antibody in post transfusion purpura. Aust NZ J Med 1990;20: 111–115.
  11. Porretti L, Marangoni F, Cofrancesco E, Neri MC, Rebulla P: Immunoglobulin classes and subclasses of platelet antibodies in a case of post–transfusion purpura (see comments). Vox Sang 1992;63:276–281.

Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: March 19, 1999
Issue release date: March 1999

Number of Print Pages: 4
Number of Figures: 1
Number of Tables: 1

ISSN: 0042-9007 (Print)
eISSN: 1423-0410 (Online)

For additional information: https://www.karger.com/VOX


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