Ophthalmologica
Original Paper
Stromal Keratitis Induced by a Unique Clinical Isolate of Herpes simplex Virus Type 1Sakai Y.a,b · Minagawa H.a · Ishibashi T.b · Inomata H.b · Mori R.aDepartments of aVirology and bOphthalmology, Faculty of Medicine, Kyushu University, Fukuoka, Japan
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Article / Publication Details
Received: October 11, 1993
Accepted: February 11, 1994
Published online: April 01, 2010
Issue release date: 1994
Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 0
ISSN: 0030-3755 (Print)
eISSN: 1423-0267 (Online)
For additional information: https://www.karger.com/OPH
Abstract
Glycoprotein C (gC)-negative clinical isolates of herpes simplex virus type 1 (HSV-1) are very rare. An HSV-1 strain (TN-1), isolated from a patient with her-petic keratitis, exhibited a gC-negative phenotype. While a gC-negative mutant showed reduced pathogenicity and failed to induce herpetic stromal keratitis (HSK) in a previously reported mouse model, TN-1 induced HSK in mice comparable to RTN-1–20–3, a gC-positive recombinant virus derived from TN-1. Virus growth in eyes and brains and the mortality of TN-1-inoculated mice were equal to or higher than those of RTN-1–20–3-inoculated mice.
© 1994 S. Karger AG, Basel
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Article / Publication Details
Received: October 11, 1993
Accepted: February 11, 1994
Published online: April 01, 2010
Issue release date: 1994
Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 0
ISSN: 0030-3755 (Print)
eISSN: 1423-0267 (Online)
For additional information: https://www.karger.com/OPH
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