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Original Paper

The Angiotensinogen AGT p.M235T Gene Polymorphism May Be Responsible for the Development of Severe Anaphylactic Reactions to Insect Venom Allergens

Niedoszytko M.a · Ratajska M.b · Chełmińska M.a · Makowiecki M.c · Malek E.b · Siemińska A.a · Limon J.b · Jassem E.a

Author affiliations

Departments of aAllergology, bBiology and Genetics, and cLaboratory Medicine, Medical University of Gdansk, Gdansk, Poland

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Int Arch Allergy Immunol 2010;153:166–172

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: October 26, 2009
Accepted: November 30, 2009
Published online: April 22, 2010
Issue release date: September 2010

Number of Print Pages: 7
Number of Figures: 2
Number of Tables: 2

ISSN: 1018-2438 (Print)
eISSN: 1423-0097 (Online)

For additional information: https://www.karger.com/IAA

Abstract

Background: Insect venom allergy (IVA) is present in 1–3% of the population. A group of patients with high specific IgE do not react to stings. In contrast, a proportion of patients with IVA have low specific IgE levels. These findings indicate that factors other than specific IgE may also be involved in IVA. Dysfunction of the renin-angiotensin system (RAS) has been described as a potential factor in IVA. The objective of this study was to determine the prevalence of angiotensin AGT p.M235T and angiotensin-converting enzyme ACE I/D, I/I, D/D gene polymorphisms in patients with IVA and to relate the presence of these gene variants to the course of IVA and the safety of treatment. Methods: A total of 107 patients with IVA and 113 controls were studied. AGT p.M235T and ACE (ID, I/I, D/D) gene polymorphisms were examined, and angiotensin I levels were measured by immunoassay. Results: The frequency of the AGT MM M235T variant was significantly higher in IVA patients (29.9%) than in controls (17%, p = 0.02). The presence of the MM M235T genotype increased the risk of grade IV reactions (odds ratio = 2.5 and 95% confidence interval 1.04–6.08). There were no differences in the prevalence of the ACE I/D polymorphism and angiotensin I levels between control groups and patients with different grades of anaphylactic reactions or patients with side effects of venom immunotherapy. Conclusion: The AGT M235T MM variant may be responsible for severe anaphylactic reactions to insect venom allergens in some patients.

© 2010 S. Karger AG, Basel


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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: October 26, 2009
Accepted: November 30, 2009
Published online: April 22, 2010
Issue release date: September 2010

Number of Print Pages: 7
Number of Figures: 2
Number of Tables: 2

ISSN: 1018-2438 (Print)
eISSN: 1423-0097 (Online)

For additional information: https://www.karger.com/IAA


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