Regular Daily Intake of Black Tea Improves Oxidative Stress Biomarkers and Decreases Serum C-Reactive Protein Levels in Type 2 Diabetic PatientsNeyestani T.R. · Shariatzade N. · Kalayi A. · Gharavi A. · Khalaji N. · Dadkhah M. · Zowghi T. · Haidari H. · Shab-bidar S.
Laboratory of Nutrition Research, National Nutrition and Food Technology Research Institute and Faculty of Nutrition and Food Technology, Shaheed Beheshti University of Medical Sciences, Tehran, Iran
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Background: This study was undertaken to evaluate the possible effects of different daily doses of black tea intake on certain oxidative stress, inflammatory and metabolic biomarkers in patients with type 2 diabetes mellitus (T2DM). Methods: Forty-six patients with known T2DM were randomly assigned either to the test (n = 23, 57.0 ± 7.9 years) or the control (n = 23, 55.4 ± 8.3 years) group. Following a one-week ‘run-in’ period, the test group received 150, 300, 450 and 600 ml of black tea extract (BTE) during the weeks 1, 2, 3 and 4, respectively. The control group received 150 ml BTE a day throughout the intervention period. Dietary, anthropometric and biochemical assessments were performed at the end of each week. Findings: Serum total antioxidant capacity was enhanced similarly in both test and control groups. However, daily intake of 2 cups of BTE by the test group showed a suppressing effect on serum malondialdehyde. Serum C-reactive protein significantly decreased and glutathione levels increased following the intake of 4 cups (600 ml) of BTE a day. Conclusion: Regular intake of BTE had anti-oxidative and anti-inflammatory effects in patients with T2DM. These findings may, to some extent, explain the mechanisms underlying the protective effects of drinking tea against cardiovascular disease.
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