Intervirology

 
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The Three-Dimensional Structure of Mimivirus

Klose T.a · Kuznetsov Y.G.b · Xiao C.c · Sun S.a · McPherson A.b · Rossmann M.G.a

Author affiliations

aDepartment of Biological Sciences, Purdue University, West Lafayette, Ind., bDepartment of Molecular Biology and Biochemistry, University of California, Irvine, Calif., and cDepartment of Chemistry, University of Texas, El Paso, Tex., USA

Corresponding Author

Dr. Michael G. Rossmann

Hockmeyer Hall of Structural Biology, Purdue University

249 S. Martin Jischke Drive

West Lafayette, IN 47907-1971 (USA)

Tel. +1 765 494 4911, Fax +1 765 496 1189, E-Mail mr@purdue.edu

Keywords: Atomic force microscopyCryo-electron microscopyMimivirus, three-dimensional structureNucleocytoplasmic large DNA viruses

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Intervirology 2010;53:268–273
https://doi.org/10.1159/000312911

Abstract

Mimivirus, the prototypic member of the new family of Mimiviridae, is the largest virus known to date. Progress has been made recently in determining the three-dimensional structure of the 0.75-µm diameter virion using cryo-electron microscopy and atomic force microscopy. These showed that the virus is composed of an outer layer of dense fibers surrounding an icosahedrally shaped capsid and an internal membrane sac enveloping the genomic material of the virus. Additionally, a unique starfish-like structure at one of the fivefold vertices, required by the virus for infecting its host, has been defined in more detail.

© 2010 S. Karger AG, Basel



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Article / Publication Details

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Published online: June 15, 2010
Issue release date: June 2010

Number of Print Pages: 6
Number of Figures: 3
Number of Tables: 0

ISSN: 0300-5526 (Print)
eISSN: 1423-0100 (Online)

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2010, Vol.53, No. 5

June 2010

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