Login to MyKarger

New to MyKarger? Click here to sign up.



Login with Facebook

Forgot your password?

Authors, Editors, Reviewers

For Manuscript Submission, Check or Review Login please go to Submission Websites List.

Submission Websites List

Institutional Login
(Shibboleth or Open Athens)

For the academic login, please select your country in the dropdown list. You will be redirected to verify your credentials.

Original Paper

Rates of Bronchopulmonary Dysplasia in Very Preterm Neonates in Europe: Results from the MOSAIC Cohort

Gortner L.a · Misselwitz B.b · Milligan D.c · Zeitlin J.d · Kollée L.e · Boerch K.f · Agostino R.g · Van Reempts P.h · Chabernaud J.-L.i · Bréart G.d · Papiernik E.j, † · Jarreau P.-H.k · Carrapato M.l · Gadzinowski J.m · Draper E.n · for the members of the MOSAIC Research Group

Author affiliations

aPediatric University Hospital, University of Saarland, Homburg, and bGeschäftsstelle Qualitätssicherung Hessen, Eschborn, Germany; cDepartment of Neonatology, Royal Victoria Infirmary, Newcastle upon Tyne, UK; dINSERM, UMR S149, Epidemiological Research Unit on Perinatal and Women’s Health, Université Pierre et Marie Curie – Paris 6, Paris, France; eRadboud University Nijmegen Medical Center, Nijmegen, The Netherlands; fDepartment of Paediatrics, Hvidovre University Hospital, Hvidovre, Denmark; gDepartment for Mother’s and Infant’s Health, Hospital San Giovanni Calibita - Fatebenefratelli, Rome, Italy; hDepartment of Neonatology, Antwerp University Hospital, University of Antwerp and Study Centre for Perinatal Epidemiology Flanders, Antwerp, Belgium; iService de Réanimation Néonatale, Hôpital Antoine Béclere, Clamart, jUniversité Paris V Réné Descartes et Service de Gynécologie-Obstétrique de Port-Royal, and kUniversité Paris V Réné Descartes et Service de Médecine Néonatale de Port-Royal, Paris, France; lDepartment of Pediatrics, Hospital Sao Sebastiao, Sta Maria de Feira, Portugal; mDepartment of Neonatology, University of Medical Sciences, Poznan, Poland; nNeonatal Unit, Department of Health Sciences, Leicester Royal Infirmary, University of Leicester, Leicester, UK

Related Articles for ""

Neonatology 2011;99:112–117

Do you have an account?

Login Information





Contact Information












By signing up for MyKarger you will automatically participate in our year-End raffle.
If you Then Do Not wish To participate, please uncheck the following box.

Yes, I wish To participate In the year-End raffle And Get the chance To win some Of our most interesting books, And other attractive prizes.


I have read the Karger Terms and Conditions and agree.



Login Information





Contact Information












By signing up for MyKarger you will automatically participate in our year-End raffle.
If you Then Do Not wish To participate, please uncheck the following box.

Yes, I wish To participate In the year-End raffle And Get the chance To win some Of our most interesting books, And other attractive prizes.


I have read the Karger Terms and Conditions and agree.



To view the fulltext, please log in

To view the pdf, please log in

Buy

  • FullText & PDF
  • Unlimited re-access via MyKarger
  • Unrestricted printing, no saving restrictions for personal use
read more

CHF 38.00 *
EUR 35.00 *
USD 39.00 *

Select

KAB

Buy a Karger Article Bundle (KAB) and profit from a discount!

If you would like to redeem your KAB credit, please log in.


Save over 20% compared to the individual article price.
Learn more

Rent/Cloud

  • Rent for 48h to view
  • Buy Cloud Access for unlimited viewing via different devices
  • Synchronizing in the ReadCube Cloud
  • Printing and saving restrictions apply

Rental: USD 8.50
Cloud: USD 20.00


Select

Subscribe

  • Access to all articles of the subscribed year(s) guaranteed for 5 years
  • Unlimited re-access via Subscriber Login or MyKarger
  • Unrestricted printing, no saving restrictions for personal use
read more

Subcription rates


Select

* The final prices may differ from the prices shown due to specifics of VAT rules.

Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: January 04, 2010
Accepted: April 08, 2010
Published online: August 23, 2010
Issue release date: February 2011

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 3

ISSN: 1661-7800 (Print)
eISSN: 1661-7819 (Online)

For additional information: https://www.karger.com/NEO

Abstract

Background: A considerable local variability in the rate of bronchopulmonary dysplasia (BPD) has been recorded previously. Objectives: The objectives of the present study were to describe regional differences in the rate of BPD in very preterm neonates from a European population-based cohort and to further delineate risk factors. Methods: 4,185 survivors to 36 weeks’ postmenstrual age of 4,984 live-born infants born at 24+0–31+6 weeks’ gestation in 2003 (the MOSAIC cohort) in 10 European regions were enrolled using predefined structured questionnaires. Results: Overall median gestational age of preterms without BPD was 30 weeks (range 23–31), median birth weight 1,320 g (range 490–3,150) compared with 27 weeks (23–31) and 900 g (370–2,460) in those with BPD. The region-specific crude rate of BPD ranged from 10.2% (Italian region) to 24.8% (UK Northern region). Maternal hypertension, immaturity, male gender, small for gestational age, Apgar <7 and region of care were associated with an increased incidence of BPD on multivariate analysis. Conclusion: A wide variability of BPD between European regions may be explained by different local practices; the strongest association however was with degree of immaturity.

© 2010 S. Karger AG, Basel


References

  1. Northway WH Jr, Rosan RC, Porter DY: Pulmonary disease following respirator therapy of hyaline-membrane disease. Bronchopulmonary dysplasia. N Engl J Med 1967;276:357–368.
  2. Jobe AJ: The new BPD: an arrest of lung development. Pediatr Res 1999;46:641–643.
  3. Avery ME, Tooley WH, Keller JB, Hurd SS, Bryan MH, Cotton RB, et al: Is chronic lung disease in low birth weight infants preventable? A survey of eight centers. Pediatrics 1987;79:26–30.
  4. Fanaroff AA, Stoll BJ, Wright LL, Carlo WA, Ehrenkranz RA, Stark AR, et al: Trends in neonatal morbidity and mortality for very low birthweight infants. Am J Obstet Gynecol 2007;196:147–148.
  5. Kinsella JP, Greenough A, Abman SH: Bronchopulmonary dysplasia. Lancet 2006;367:1421–1431.
  6. Vanpee M, Walfridsson-Schultz U, Katz-Salamon M, Zupancic JA, Pursley D, Jonsson B: Resuscitation and ventilation strategies for extremely preterm infants: a comparison study between two neonatal centers in Boston and Stockholm. Acta Paediatr 2007;96:10–16.
  7. Makri V, Hospes B, Stoll-Becker S, Borkhardt A, Gortner L: Polymorphisms of surfactant protein B encoding gene: modifiers of the course of neonatal respiratory distress syndrome? Eur J Pediatr 2002;161:604–608.
  8. Abman SH, Mourani PM, Sontag M: Bronchopulmonary dysplasia: a genetic disease. Pediatrics 2008;122:658–659.
  9. Payne NR, LaCorte M, Sun S, Karna P, Lewis-Hunstiger M, Goldsmith JP: Evaluation and development of potentially better practices to reduce bronchopulmonary dysplasia in very low birth weight infants. Pediatrics 2006;118(suppl 2):S65–S72.
  10. Zeitlin J, Papiernik E, Breart G, Draper E, Kollée L: Presentation of the European project models of organising access to intensive care for very preterm births in Europe (MOSAIC) using European diversity to explore models for the care of very preterm babies. Eur J Obstet Gynecol Reprod Biol 2005;118:272–274.
  11. Van Reempts P, Gortner L, Milligan D, Cuttini M, Petrou S, Agostino R, et al: Characteristics of neonatal units that care for very preterm infants in Europe: results from the MOSAIC study. Pediatrics 2007;120:e815–e825.
  12. Zeitlin J, Draper ES, Kollée L, Milligan D, Boerch K, Agostino R, et al: Differences in rates and short-term outcome of live births before 32 weeks of gestation in Europe in 2003: results from the MOSAIC cohort. Pediatrics 2008;121:e936–e944.
  13. Verder H: Nasal CPAP has become an indispensable part of the primary treatment of newborns with respiratory distress syndrome. Acta Paediatr 2007;96:482–484.
  14. Morley CJ, Davis PG, Doyle LW, Brion LP, Hascoet JM, Carlin JB: Nasal CPAP or intubation at birth for very preterm infants. N Engl J Med 2008;358:700–708.
  15. Poets CF, Sens B: Changes in intubation rates and outcome of very low birth weight infants: a population-based study. Pediatrics 1996;98:24–27.
  16. Tin W, Milligan DW, Pennefather P, Hey E: Pulse oximetry, severe retinopathy, and outcome at one year in babies of less than 28 weeks’ gestation. Arch Dis Child Fetal Neonatal Ed 2001;84:F106–F110.
  17. Marttila R, Haataja R, Ramet M, Lofgren J, Hallman M: Surfactant protein B polymorphism and respiratory distress syndrome in premature twins. Hum Genet 2003;112:18–23.
  18. Thomas W, Speer CP: Nonventilatory strategies for prevention and treatment of bronchopulmonary dysplasia – what is the evidence? Neonatology 2008;94:150–159.
  19. Halliday HL, Ehrenkranz RA, Doyle LW: Late (>7 days) postnatal corticosteroids for chronic lung disease in preterm infants. Cochrane Database Syst Rev 2009(1):CD001145.
  20. Been JV, Zimmermann LJ: Histological chorioamnionitis and respiratory outcome in preterm infants. Arch Dis Child Fetal Neonatal Ed 2009;94:F218–F225.

Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: January 04, 2010
Accepted: April 08, 2010
Published online: August 23, 2010
Issue release date: February 2011

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 3

ISSN: 1661-7800 (Print)
eISSN: 1661-7819 (Online)

For additional information: https://www.karger.com/NEO


Copyright / Drug Dosage / Disclaimer

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.