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Original Research

Preliminary Investigation of the Clinical Value of Vascular Endothelial Growth Factor and Hypoxia-Inducible Factor-1α in Pericardial Fluid in Diagnosing Malignant and Tuberculous Pericardial Effusion

Liu J.a, b · Zeng Y.a · Ma W.a · Chen S.a · Zheng Y.a · Ye S.a · Lan L.a · Weig H.-J.c · Liu Q.a

Author affiliations

aDepartment of Internal Cardiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, bCentral Hospital of Wuhan, Wuhan, China; cDepartment of Internal Cardiology, University Hospital of Tuebingen, University of Tuebingen, Tuebingen, Germany

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Cardiology 2010;116:37–41

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Article / Publication Details

First-Page Preview
Abstract of Original Research

Received: November 16, 2009
Accepted: January 29, 2010
Published online: April 27, 2010
Issue release date: June 2010

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 2

ISSN: 0008-6312 (Print)
eISSN: 1421-9751 (Online)

For additional information: https://www.karger.com/CRD

Abstract

Objectives: To investigate the clinical value of vascular endothelial growth factor (VEGF) and hypoxia-inducible factor-1α (HIF-1α) in diagnosing malignant and tuberculous pericardial effusion. Methods: Eighty patients with exudative pericardial effusion undergoing pericardiocentesis and drainage were divided into 2 groups, namely those with malignancy and those with tuberculosis. The levels of HIF-1α, VEGF, lactate dehydrogenase (LDH) and adenosine deaminase (ADA) in pericardial fluid and serum were measured. Routine and cytological examination of pericardial fluid, clinical characteristics and some blood parameters were compared between the 2 groups. Results: There were 33 patients with tuberculous pericardial effusion and 47 with malignant pericardial effusion. The levels of VEGF and HIF-1α in pericardial fluid in the malignancy group were significantly higher than those in the tuberculosis group (p < 0.01), and there was a moderate positive correlation between the levels of VEGF and HIF-1α (r = 0.79, p < 0.01). The sensitivity and specificity of combining VEGF and HIF-1α were 90.8 and 88.3%, respectively. The 2 groups showed no differences with regard to gender distribution, occurrence of fever, erythrocyte sedimentation rate or the levels of hemoglobin, LDH, ADA, serum HIF-1α and VEGF. Conclusions: Both VEGF and HIF-1α in pericardial fluid have determinative value in the differential diagnosis of malignant and tuberculous pericardial effusion.

© 2010 S. Karger AG, Basel


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    External Resources
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Article / Publication Details

First-Page Preview
Abstract of Original Research

Received: November 16, 2009
Accepted: January 29, 2010
Published online: April 27, 2010
Issue release date: June 2010

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 2

ISSN: 0008-6312 (Print)
eISSN: 1421-9751 (Online)

For additional information: https://www.karger.com/CRD


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