Effect of Black-Currant Extract on Negative Lens-Induced Ocular Growth in ChicksIida H.a · Nakamura Y.a · Matsumoto H.a · Takeuchi Y.a · Harano S.b · Ishihara M.b · Katsumi O.c
aFood and Health R&D Laboratories, Meiji Seika Kaisha Ltd., Sakado, and bAgricultural and Veterinary Research Laboratories, Meiji Seika Kaisha Ltd., Yokohama, and cNishi Kasai Inouye Eye Pediatric Eye Clinic, Tokyo, Japan
Do you have an account?
- Rent for 48h to view
- Buy Cloud Access for unlimited viewing via different devices
- Synchronizing in the ReadCube Cloud
- Printing and saving restrictions apply
Rental: USD 8.50
Cloud: USD 20.00
Article / Publication Details
Aim: To evaluate the effects of orally administered black-currant (BC) extract on the enlargement of globe component dimensions induced in chicks by wearing negative lenses. Methods: Negative lenses (–8 D) were worn on the right eyes by 8-day-old chicks, and their fellow eyes acted as controls. BC extract and distilled water (vehicle control) were orally administered once a day for 3 days. To confirm the effect of BC anthocyanins (BCAs), they were intravenously administered once a day for 3 days. Dimensions of globe components of right eyes and fellow eyes were measured with an A-scan ultrasound instrument on the third day (day 4) after placement of the negative lenses. Results: Orally administered BC extract significantly inhibited enlargement of vitreous-chamber depth, axial and ocular lengths in a dose-dependent manner when compared to controls. Intravenously administered BCAs also inhibited elongation of vitreous-chamber depth and axial length when compared to controls. Conclusions: This is the first evidence that BC extract and BCAs could inhibit enlargement of globe component dimensions in a negative lens-induced chick myopia model.
© 2010 S. Karger AG, Basel
- Nakaishi H, Matsumoto H, Tominaga S, Hirayama M: Effects of black current anthocyanoside intake on dark adaptation and VDT work-induced transient refractive alteration in healthy humans. Altern Med Rev 2000;5:553–562.
- Matsumoto H, Inaba H, Kishi M, Tominaga S, Hirayama M, Tsuda T: Orally administered delphinidin 3-rutinoside and cyanidin 3-rutinoside are directly absorbed in rats and humans and appear in the blood as the intact forms. J Agric Food Chem 2001;49:1546–1551.
- Matsumoto H, Nakamura Y, Iida H, Ito K, Ohguro H: Comparative assessment of distribution of black currant anthocyanins in rabbit and rat ocular tissues. Exp Eye Res 2006;83:348–356.
- Matsumoto H, Kamm KE, Stull JT, Azuma H: Delphinidin-3-rutinoside relaxes the bovine ciliary smooth muscle through activation of ETB receptor and NO/cGMP pathway. Exp Eye Res 2005;80:313–322.
- Matsumoto H, Nakamura Y, Tachibanaki S, Kawamura S, Hirayama M: Stimulatory effect of cyanidin 3-glycosides on the regeneration of rhodopsin. J Agric Food Chem 2003;51:3560–3563.
- Wong TY, Loon SC, Saw SM: The epidemiology of age-related eye diseases in Asia. Br J Ophthalmol 2006;90:506–511.
- Mutti DO, Zadnik K, Adams AJ: Myopia. The nature versus nurture debate goes on. Invest Ophthalmol Vis Sci 1996;37:952–957.
- Saw SM, Katz J, Schein OD, Chew SJ, Chan TK: Epidemiology of myopia. Epidemiol Rev 1996;18:175–187.
- Hyman L, Gwiazda J, Hussein M, et al: Relationship of age, sex, and ethnicity with myopia progression and axial elongation in the correction of myopia evaluation trial. Arch Ophthalmol 2005;123:977–987.
- Rouse MW, Hutter RF, Shiftlett R: A normative study of the accommodative lag in elementary school children. Am J Optom Physiol Opt 1984;61:693–697.
- Schaeffel F, Glasser A, Howland HC: Accommodation, refractive error and eye growth in chickens. Vision Res 1988;28:639–657.
- Hung LF, Crawford ML, Smith EL: Spectacle lenses alter eye growth and the refractive status of young monkeys. Nat Med 1995;1:761–765.
- Whatham AR, Judge SJ: Compensatory changes in eye growth and refraction induced by daily wear of soft contact lenses in young marmosets. Vision Res 2001;41:267–273.
- Cottriall CL, McBrien NA: The M1 muscarinic antagonist pirenzepine reduces myopia and eye enlargement in the tree shrew. Invest Ophthalmol Vis Sci 1996;37:1368–1379.
- Wildsoet C, Wallman J: Choroidal and scleral mechanisms of compensation for spectacle lenses in chicks. Vision Res 1995;35:1175–1194.
- Wildsoet C: Neural pathways subserving negative lens-induced emmetropization in chicks – insights from selective lesions of the optic nerve and ciliary nerve. Curr Eye Res 2003;27:371–385.
- Guo SS, Sivak JG, Callender MG, Diehl-Jones B: Retinal dopamine and lens-induced refractive errors in chicks. Curr Eye Res 1995;14:385–389.
- Stone RA, Lin T, Laties AM, Iuvone PM: Retinal dopamine and form-deprivation myopia. Proc Natl Acad Sci USA 1989;86:704–706.
- Buck C, Schaeffel F, Simon P, Feldkaemper M: Effects of positive and negative lens treatment on retinal and choroidal glucagon and glucagon receptor mRNA levels in the chicken. Invest Ophthalmol Vis Sci 2004;45:402–409.
- Feldkaemper MP, Schaeffel F: Evidence for a potential role of glucagon during eye growth regulation in chicks. Vis Neurosci 2002;19:755–766.
- Bitzer M, Feldkaemper M, Schaeffel F: Visually induced changes in components of the retinoic acid system in fundal layers of the chick. Exp Eye Res 2000;70:97–106.
- Seko Y, Shimokawa H, Tokoro T: In vivo and in vitro association of retinoic acid with form-deprivation myopia in the chick. Exp Eye Res 1996;63:443–452.
- McFadden SA, Howlett MH, Mertz JR: Retinoic acid signals the direction of ocular elongation in the guinea pig eye. Vision Res 2004;44:643–653.
- Seltner RL, Stell WK: The effect of vasoactive intestinal peptide on development of form deprivation myopia in the chick: a pharmacological and immunocytochemical study. Vision Res 1995;35:1265–1270.
- Stone RA, Laties AM, Raviola E, Wiesel TN: Increase in retinal vasoactive intestinal polypeptide after eyelid fusion in primates. Proc Natl Acad Sci USA 1988;85:257–260.
- Mertz JR, Wallman J: Choroidal retinoic acid synthesis: a possible mediator between refractive error and compensatory eye growth. Exp Eye Res 2000;70:519–527.
- McFadden SA, Howlett MH, Mertz JR, Wallman J: Acute effects of dietary retinoic acid on ocular components in the growing chick. Exp Eye Res 2006;83:949–961.
- Rohrer B, Spira AW, Stell WK: Apomorphine blocks form-deprivation myopia in chickens by a dopamine D2-receptor mechanism acting in retina or pigmented epithelium. Vis Neurosci 1993;10:447–453.
- Jin N, Stjernschantz J: Effects of prostaglandins on form deprivation myopia in the chick. Acta Ophthalmol Scand 2000;78:495–500.
- Seko Y, Shimokawa H, Tokoro T: Expression of bFGF and TGF-β2 in experimental myopia in chicks. Invest Ophthalmol Vis Sci 1995;36:1183–1187.
- Vessey KA, Lencses KA, Rushforth DA, Hruby VJ, Stell WK: Glucagon receptor agonists and antagonists affect the growth of the chick eye: a role for glucagonergic regulation of emmetropization? Invest Ophthalmol Vis Sci 2005;46:3922–3931.
- Cooke DN, Thomasset S, Boocock DJ, et al: Development of analyses by high-performance liquid chromatography and liquid chromatography/tandem mass spectrometry of bilberry (Vaccinium myrtilus) anthocyanins in human plasma and urine. J Agric Food Chem 2006;54:7009–7013.
- Irving EL, Sivak JG, Callender MG: Refractive plasticity of the developing chick eye. Ophthalmic Physiol Opt 1992;12:448–456.
- Metlapally S, McBrien NA: The effect of positive lens defocus on ocular growth and emmetropization in the tree shrew. J Vis 2008;8:1–12.
- Fujikado T, Kawasaki Y, Suzuki A, Ohmi G, Tano Y: Retinal function with lens-induced myopia compared with form-deprivation myopia in chicks. Graefes Arch Clin Exp Ophthalmol 1997;235:320–324.
- Diether S, Schaeffel F, Lambrou GN, Fritsch C, Trendelenburg AU: Effects of intravitreally and intraperitoneally injected atropine on two types of experimental myopia in chicken. Exp Eye Res 2007;84:266–274.
- Rickers M, Schaeffel F: Dose-dependent effects of intravitreal pirenzepine on deprivation myopia and lens-induced refractive errors in chickens. Exp Eye Res 1995;61:509–516.
- Chua WH, Balakrishnan V, Chan YH, et al: Atropine for the treatment of childhood myopia. Ophthalmology 2006;113:2285–2291.
- Siatkowski RM, Cotter SA, Crockett RS, Miller JM, Novack GD, Zadnik K: Two-year multicenter, randomized, double-masked, placebo-controlled, parallel safety and efficacy study of 2% pirenzepine ophthalmic gel in children with myopia. J AAPOS 2008;12:332–339.
- Irving EL, Callender MG, Sivak JG: Inducing myopia, hyperopia, and astigmatism in chicks. Optom Vis Sci 1991;68:364–368.
- Kee CS, Marzani D, Wallman J: Differences in time course and visual requirements of ocular responses to lenses and diffusers. Invest Ophthalmol Vis Sci 2001;42:575–583.
- Rose KA, Morgan IG, Ip J, et al: Outdoor activity reduces the prevalence of myopia in children. Ophthalmology 2008;115:1279–1285.
- Dirani M, Tong L, Gazzard G, et al: Outdoor activity and myopia in Singapore teenage children. Br J Ophthalmol 2009;93:997–1000.
- Mutti DO, Zadnik K: Has near work’s star fallen? Optom Vis Sci 2009;86:76–78.
Article / Publication Details
Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.