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Cardiorenal Syndromes in Critical Care

Editor(s): Ronco C. (Vicenza) 
Bellomo R. (Melbourne, Vic.) 
McCullough P.A. (Royal Oak, Mich.) 
Cover

Pathophysiology of Acute Kidney Injury

Pathophysiology of AKI: Injury and Normal and Abnormal Repair

Bonventre J.V.

Author affiliations

Renal Division, Brigham and Women’s Hospital and Department of Medicine, Harvard Medical School, and the Harvard-Massachusetts Institute of Technology, Division of Health Sciences and Technology, Boston, Mass., USA

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Ronco C, Bellomo R, McCullough PA (eds): Cardiorenal Syndromes in Critical Care. Contrib Nephrol. Basel, Karger, 2010, vol 165, pp 9–17

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Article / Publication Details

First-Page Preview
Abstract of Pathophysiology of Acute Kidney Injury

Published online: April 20, 2010
Cover Date: 2010

Number of Print Pages: 9
Number of Figures: 0
Number of Tables: 0

ISBN: 978-3-8055-9472-1 (Print)
eISBN: 978-3-8055-9473-8 (Online)

Abstract

The pathophysiology of acute kidney injury involves a complex interplay among vascular, tubular, and inflammatory factors followed by a repair process that can either restore epithelial differentiation and function to normal or result in progressive fibrotic chronic kidney disease. Innate and acquired immunity play an important role in the injury phase, in the regulation of the inflammatory response, and in processes related to repair of the epithelial layer. Recent data change the direction of focus of the role of the epithelium in fibrosis and attributes myelofibroblast production to perivascular and interstitial fibroblasts. The epithelium plays an important role in abnormal repair through a recently defined link between cell cycle arrest of the epithelial cell and profibrogenic cytokine production.

© 2010 S. Karger AG, Basel


References

  1. Zuk A, Bonventre JV, Brown D, Matlin KS: Polarity, integrin, and extracellular matrix dynamics in the postischemic rat kidney. Am J Physiol 1998;275:C711-C731
  2. Thadhani R, Pascual M, Bonventre JV: Acute renal failure. N Engl J Med 1996;334:1448-1460
  3. Zuk A, Bonventre JV, Matlin KS: Expression of fibronectin splice variants in the postischemic rat kidney. Am J Physiol 2001;280:F1037-F1053
  4. Heyman SN, Rosenberger C, Rosen S: Experimental ischemia-reperfusion: biases and myths - the proximal vs. distal hypoxic tubular injury debate revisited. Kidney Int 2009;77:9-16
  5. Han WK, Bailly V, Abichandani R, Thadhani R, Bonventre JV: Kidney injury molecule-1: a novel biomarker for human renal proximal tubule injury. Kidney Int 2002;62:237-244
  6. Vaidya VS, Waikar SS, Ferguson MA, Collings FB, Sunderland K, Gioules C, Bradwin G, Matsouaka R, Betensky RA, Curhan GC, Bonventre JV: Urinary biomarkers for sensitive and specific detection of acute kidney injury in humans. Clin Transl Sci 2008;1:200-208
  7. Conger J: Hemodynamic factors in acute renal failure. Adv Ren Replace Ther 1997;4:(suppl 1)25-37
  8. Conger JD: Vascular abnormalities in the maintenance of acute renal failure. Circ Shock 1983;11:235-244
  9. Kwon O, Hong SM, Ramesh G: Diminished NO generation by injured endothelium and loss of macula densa nNOS may contribute to sustained acute kidney injury after ischemia-reperfusion. Am J Physiol 2009;296:F25-F33
  10. Park KM, Chen A, Bonventre JV: Prevention of kidney ischemia/reperfusion-induced functional injury and JNK, p38, and MAPK kinase activation by remote ischemic pretreatment. J Biol Chem 2001;276:11870-11876
  11. Basile DP, Fredrich K, Chelladurai B, Leonard EC, Parrish AR: Renal ischemia reperfusion inhibits VEGF expression and induces ADAMTS-1, a novel VEGF inhibitor. Am J Physiol 2008;294:F928-F936
  12. Zouggari Y, Ait-Oufella H, Waeckel L, Vilar J, Loinard C, Cochain C, Recalde A, Duriez M, Levy BI, Lutgens E, Mallat Z, Silvestre JS: Regulatory T cells modulate postischemic neovascularization. Circulation 2009;120:1415-1425
  13. Leemans JC, Stokman G, Claessen N, Rouschop KM, Teske GJ, Kirschning CJ, Akira S, van der Poll T, Weening JJ, Florquin S: Renal-associated TLR2 mediates ischemia/ reperfusion injury in the kidney. J Clin Invest 2005;115:2894-2903
  14. Pulskens WP, Teske GJ, Butter LM, Roelofs JJ, van der Poll T, Florquin S, Leemans JC: Toll-like receptor-4 coordinates the innate immune response of the kidney to renal ischemia/reperfusion injury. PloS One 2008;3:e3596
  15. Kelly KJ, Williams WW, Colvin RB, Bonventre JV: Antibody to intercellular adhesion molecule-1 protects the kidney against ischemic injury. Proc Natl Acad Sci USA 1994;91:812-816
  16. Kelly KJ, Williams WW, Colvin RB, Meehan SM, Springer TA, Gutierrez-Ramos JC, Bonventre JV: Intercellular adhesion molecule-1-deficient mice are protected against renal ischemia. J Clin Invest 1996;97:1056-1063
  17. Sanz MJ, Johnston B, Issekutz A, Kubes P: Endothelin causes P-selectin-dependent leukocyte rolling and adhesion within rat mesenteric microvessels. Am J Physiol 1999;277:H1823-H30
  18. Linas S, Whittenburg D, Repine JE: Nitric oxide prevents neutrophil-mediated acute renal failure. Am J Physiol 1997;272:F48-F54
  19. Li L, Huang L, Vergis AL, Ye H, Bajwa A, Narayan V, Strieter RM, Rosin DL, Okusa MD: IL-17 produced by neutrophils regulates IFN- γ-mediated neutrophil migration in mouse kidney ischemia-reperfusion injury. J Clin Invest 2010;120:331-342
  20. Rabb H, Daniels F, O’Donnell M, Haq M, Saba SR, Keane W, Tang WW: Pathophysiological role of T lymphocytes in renal ischemia-reperfusion injury in mice. Am J Physiol 2000;279:F525-F531
  21. Park P, Haas M, Cunningham PN, Bao L, Alexander JJ, Quigg RJ: Injury in renal ischemia-reperfusion is independent from immunoglobulins and T lymphocytes. Am J Physiol 2002;282:F352-F357
  22. Burne-Taney MJ, Yokota-Ikeda N, Rabb H: Effects of combined T- and B-cell deficiency on murine ischemia reperfusion injury. Am J Transplant 2005;5:1186-1193
  23. Gandolfo MT, Jang HR, Bagnasco SM, Ko GJ, Agreda P, Satpute SR, Crow MT, King LS, Rabb H: Foxp3+ regulatory T cells participate in repair of ischemic acute kidney injury. Kidney Int 2009;76:717-729
  24. Ricardo SD, van Goor H, Eddy AA: Macrophage diversity in renal injury and repair. J Clin Invest 2008;118:3522-3530
  25. Li L, Huang L, Sung SS, Vergis AL, Rosin DL, Rose CE, Jr, Lobo PI, Okusa MD: The chemokine receptors CCR2 and CX3CR1 mediate monocyte/macrophage trafficking in kidney ischemia-reperfusion injury. Kidney Int 2008;74:1526-1537
  26. John R, Nelson PJ: Dendritic cells in the kidney. J Am Soc Nephrol 2007;18:2628-2635
  27. Reis e Sousa C: Dendritic cells in a mature age. Nat Rev Immunol 2006;6:476-483
  28. Homeister JW, Lucchesi BR: Complement activation and inhibition in myocardial ischemia and reperfusion injury. Annu Rev Pharmacol Toxicol 1994;34:17-40
  29. Humphreys BD, Valerius MT, Kobayashi A, Mugford JW, Soeung S, Duffield JS, McMahon AP, Bonventre JV: Intrinsic epithelial cells repair the kidney after injury. Cell Stem Cell 2008;2:284-291
  30. Forbes JM, Hewitson TD, Becker GJ, Jones CL: Ischemic acute renal failure: long-term histology of cell and matrix changes in the rat. Kidney Int 2000;57:2375-2385
  31. Macedo E, Bouchard J, Mehta RL: Renal recovery following acute kidney injury. Curr Opin Crit Care 2008;14:660-665
  32. Humphreys BD, Lin SL, Kobayashi A, Hudson TE, Nowlin BT, Bonventre JV, Valerius MT, McMahon AP, Duffield JS: Fate tracing reveals the pericyte and not epithelial origin of myofibroblasts in kidney fibrosis. Am J Pathol 2010;176:85-97
  33. Yang L, Besschetnova TY, Brooks CR, Shah JV, Bonventre JV: Epithelial cell cycle arrest in G2/M mediates kidney fibrosis after injury. Nat Med 2010;(in press)
  34. Ishani A, Xue JL, Himmelfarb J, Eggers PW, Kimmel PL, Molitoris BA, Collins AJ: Acute kidney injury increases risk of ESRD among elderly. J Am Soc Nephrol 2009;20:223-228

Article / Publication Details

First-Page Preview
Abstract of Pathophysiology of Acute Kidney Injury

Published online: April 20, 2010
Cover Date: 2010

Number of Print Pages: 9
Number of Figures: 0
Number of Tables: 0

ISBN: 978-3-8055-9472-1 (Print)
eISBN: 978-3-8055-9473-8 (Online)


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