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Original Paper

Erythrocyte Indices in the Assessment of Iron Status in Dialysis-Dependent Patients with End-Stage Renal Disease on Continuous Erythropoietin Receptor Activator versus Epoetin β Therapy

Jonckheere S.a · Dierick J.a · Vanhouteghem H.a · Devleeschouwer M.b · Stove V.c

Author affiliations

Departments of aClinical Chemistry and bNephrology, Algemeen Ziekenhuis Maria Middelares, and cDepartment of Clinical Chemistry, Ghent University Hospital, Ghent, Belgium

Related Articles for ""

Acta Haematol 2010;124:27–33

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: February 11, 2010
Accepted: March 30, 2010
Published online: July 07, 2010
Issue release date: July 2010

Number of Print Pages: 7
Number of Figures: 3
Number of Tables: 3

ISSN: 0001-5792 (Print)
eISSN: 1421-9662 (Online)

For additional information: https://www.karger.com/AHA

Abstract

Background: European guidelines stress that iron status should be regularly assessed for the optimal management of renal anemia. These guidelines include the hemoglobin content of reticulocytes and the percentage of hypochromic RBC as markers for functional iron deficiency. Recently, equivalents of these indices have become available on the automated hematology analyzer Sysmex XE-2100, these being reticulocyte hemoglobin equivalent (Ret-He) and DF-HYPO XE, respectively. Methods: In a prospective study, we closely monitored these parameters in dialysis-dependent patients with end-stage renal disease during the switch from a first-generation epoetin (EPO) once weekly to a third-generation EPO [continuous erythropoietin receptor activator (CERA)] once monthly. As a control, patients staying on EPO β were monitored. Results: During follow-up, no changes in erythrocyte indices were noticed in the EPO β group. By contrast, in the CERA group, a decrease in Ret-He and an increase in DF-HYPO XE were transiently found 7–10 days after administration. The transient state of functional iron deficiency could not be prevented by extra intravenous iron. Conclusion: Fluctuations in Ret-He and DF-HYPO XE have to be taken into account when these parameters are used for the assessment of iron-deficient states. We suggest that a fixed time point in the CERA schedule should be chosen for iron monitoring.

© 2010 S. Karger AG, Basel


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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: February 11, 2010
Accepted: March 30, 2010
Published online: July 07, 2010
Issue release date: July 2010

Number of Print Pages: 7
Number of Figures: 3
Number of Tables: 3

ISSN: 0001-5792 (Print)
eISSN: 1421-9662 (Online)

For additional information: https://www.karger.com/AHA


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