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Original Paper

Visual Acuity and Foveal Thickness after Vitrectomy for Macular Edema

Noma H.a, b · Funatsu H.a · Mimura T.c · Shimada K.d

Author affiliations

aDepartment of Ophthalmology, Yachiyo Medical Center, Tokyo Women’s Medical University, Chiba, bDepartment of Ophthalmology and Visual Science, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, cDepartment of Ophthalmology, University of Tokyo Graduate School of Medicine, and dDepartment of Biostatistics, STATZ Institute Inc., Tokyo, Japan

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Ophthalmologica 2010;224:367–373

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: April 09, 2009
Accepted: August 21, 2009
Published online: May 04, 2010
Issue release date: October 2010

Number of Print Pages: 7
Number of Figures: 3
Number of Tables: 1

ISSN: 0030-3755 (Print)
eISSN: 1423-0267 (Online)

For additional information: http://www.karger.com/OPH

Abstract

The outcome of vitrectomy for macular edema was examined in patients with central retinal vein occlusion (CRVO), as well as whether vascular endothelial growth factor (VEGF) and interleukin-6 (IL-6) levels in vitreous fluid influence the visual prognosis and macular edema. Twenty-six consecutive patients with CRVO and macular edema underwent vitrectomy. Best-corrected visual acuity, retinal thickness, and the VEGF and IL-6 levels in vitreous fluid were measured before and after surgery. Both visual acuity and retinal thickness were significantly improved at 6 months postoperatively (p = 0.0114 and p < 0.0001, respectively). The vitreous VEGF level was significantly higher in patients who showed less improvement of visual acuity (p = 0.0182). In contrast, a high vitreous VEGF level was associated with greater improvement of macular edema (p = 0.0199). These results suggest that the vitreous VEGF level may be correlated with the visual prognosis and changes of macular edema in CRVO patients after vitrectomy.

© 2010 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: April 09, 2009
Accepted: August 21, 2009
Published online: May 04, 2010
Issue release date: October 2010

Number of Print Pages: 7
Number of Figures: 3
Number of Tables: 1

ISSN: 0030-3755 (Print)
eISSN: 1423-0267 (Online)

For additional information: http://www.karger.com/OPH


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