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Case Report

Acquired Haemophilia A and Kaposi’s Sarcoma in an HIV-Negative, HHV-8-Positive Patient: A Discussion of Mechanism and Aetiology

Cashin P.a · Lundberg L.G.d · Hagberg H.b · Ejerblad E.c · Karlbom U.a

Author affiliations

aSection of Surgery, Department of Surgical Sciences, bSection of Oncology, Department of Oncology, Radiology and Clinical Immunology, and cSection of Haematology, Department of Medical Sciences, Uppsala University, Uppsala, and dSection of Coagulation Disorders, Department of Haematology, Karolinska University Hospital, Stockholm, Sweden

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Acta Haematol 2010;124:40–43

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Article / Publication Details

First-Page Preview
Abstract of Case Report

Received: December 08, 2009
Accepted: April 23, 2010
Published online: July 03, 2010
Issue release date: July 2010

Number of Print Pages: 4
Number of Figures: 3
Number of Tables: 0

ISSN: 0001-5792 (Print)
eISSN: 1421-9662 (Online)

For additional information: https://www.karger.com/AHA

Abstract

Background: Acquired haemophilia A (AHA) is a rare bleeding disorder caused by an imbalance in the immune system leading to the production of factor VIII antibodies. In half of the cases, the underlying cause is not known. Clinical History: We report on a patient with AHA and Kaposi’s sarcoma (KS), which is caused by the human herpes virus 8 (HHV-8). The patient presented with appendicitis and developed several severe post-operative haemorrhages. He spent 3 months in intensive care due to long and difficult infections. While recuperating on the ward, the patient developed KS in the lower extremities. He had a positive HHV-8 infection. Discussion/Conclusion: Due to its latency and replication in the lymphoid system, HHV-8 is an ideal candidate for causing an imbalance in the immune system in susceptible patients. Our conclusion is that AHA was caused or prompted by the HHV-8 infection. Since HHV-8 viral infection is often subclinical, viral testing might be an important tool in acquired haemophilia diagnostics even when viral symptoms are absent.

© 2010 S. Karger AG, Basel


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Article / Publication Details

First-Page Preview
Abstract of Case Report

Received: December 08, 2009
Accepted: April 23, 2010
Published online: July 03, 2010
Issue release date: July 2010

Number of Print Pages: 4
Number of Figures: 3
Number of Tables: 0

ISSN: 0001-5792 (Print)
eISSN: 1421-9662 (Online)

For additional information: https://www.karger.com/AHA


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