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Original Research Article

Hysterectomy, Oophorectomy and Risk of Dementia: A Nationwide Historical Cohort Study

Phung T.K.T.a · Waltoft B.L.c · Laursen T.M.c · Settnes A.d · Kessing L.V.b · Mortensen P.B.c · Waldemar G.a

Author affiliations

aMemory Disorders Research Group, Department of Neurology, and bDepartment of Psychiatry, Neuroscience Center, Copenhagen University Hospital Rigshospitalet, Copenhagen, cNational Center for Register-Based Research, Aarhus University, Aarhus, and dDepartment of Obstetrics and Gynecology, Hilleroed University Hospital, Hilleroed, Denmark

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Dement Geriatr Cogn Disord 2010;30:43–50

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Article / Publication Details

First-Page Preview
Abstract of Original Research Article

Accepted: April 21, 2010
Published online: July 30, 2010
Issue release date: August 2010

Number of Print Pages: 8
Number of Figures: 1
Number of Tables: 4

ISSN: 1420-8008 (Print)
eISSN: 1421-9824 (Online)

For additional information: https://www.karger.com/DEM

Abstract

Background: This study aimed to determine whether there is an association between hysterectomy and dementia. Methods: All female Danish residents born before 1966, alive on their 40th birthday and without a dementia diagnosis prior to 1977 (n = 2,313,388) were followed from January 1, 1977, or the age of 40, whichever came later, until dementia diagnosis, death, emigration or December 31, 2006, whichever came first. The relative risks (RR) for developing dementia in women with hysterectomy/oophorectomy compared to referent women were calculated. Results: Overall, hysterectomy did not increase the risk of dementia. When stratified by age at dementia diagnosis, hysterectomy was associated with an increased risk for early-onset dementia before the age of 50: hysterectomy alone (RR = 1.38, 95% confidence interval (CI) = 1.07–1.78), with unilateral oophorectomy (RR = 2.10, 95% CI = 1.28–3.45), with bilateral oophorectomy (RR = 2.33, 95% CI = 1.44–3.77). The younger the age at hysterectomy/oophorectomy, the greater was the risk. Conclusions: Although statistically significant, the association between premenopausal hysterectomy and early-onset dementia is uncertain due to study limitations. Premenopausal bilateral oophorectomy is associated with a higher risk, suggesting a dose effect of premature estrogen deficiency on dementia. The age-dependent effect suggests that the younger brain is probably more vulnerable to estrogen deficiency.

© 2010 S. Karger AG, Basel


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    External Resources
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Article / Publication Details

First-Page Preview
Abstract of Original Research Article

Accepted: April 21, 2010
Published online: July 30, 2010
Issue release date: August 2010

Number of Print Pages: 8
Number of Figures: 1
Number of Tables: 4

ISSN: 1420-8008 (Print)
eISSN: 1421-9824 (Online)

For additional information: https://www.karger.com/DEM


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