Hormone Research in Paediatrics

Original Paper

Bone Mass and Bone Metabolism Markers during Adolescence: The HELENA Study

Gracia-Marco L.a, b · Vicente-Rodríguez G.a, c · Valtueña J.d · Rey-López J.P.a, b · Díaz Martínez A.E.e · Mesana M.I.a, b · Widhalm K.f · Ruiz J.R.g · González-Gross M.d, h · Castillo M.J.i · Moreno L.A.a, b · on behalf of the HELENA Study Group

Author affiliations

aGENUD (Growth, Exercise, NUtrition and Development) Research Group and bSchool of Health Science (EUCS), Department of Physiotherapy and Nursing, University of Zaragoza, Zaragoza, cFaculty of Health and Sport Science (FCSD), Department of Physiotherapy and Nursing, University of Zaragoza, Huesca, dDepartment of Health and Human Performance, Faculty of Physical Activity and Sport Sciences-INEF, Technical University of Madrid, and eClinical Laboratory, Sport Medicine Center, Consejo Superior de Deportes, Madrid, Spain; fDivision of Clinical Nutrition and Prevention, Department of Pediatrics, Medical University of Vienna, Vienna, Austria; gUnit for Preventive Nutrition, Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden; hInstitut für Ernährungs- und Lebensmittelwissenschaften, Humanernährung, Rheinische Friedrich-Wilhelms Universität, Bonn, Germany; iDepartment of Physiology, School of Medicine, University of Granada, Granada, Spain

Keywords: AdolescentsGrowthOsteocalcinPropeptide of type I procollagenβ-Isomerized C-telopeptide

Related Articles for ""
Horm Res Paediatr 2010;74:339–350
https://doi.org/10.1159/000314965

Log in to MyKarger to check if you already have access to this content.




Forgot your password
Sign up to MyKarger

Buy

  • FullText & PDF
  • Unlimited re-access via MyKarger
  • Unrestricted printing, no saving restrictions for personal use
read more
CHF 38.00 *
EUR 35.00 *
USD 39.00 *

Select

KAB

Buy a Karger Article Bundle (KAB) and profit from a discount!


If you would like to redeem your KAB credit, please log in.

Save over 20% compared to the individual article price.

Learn more

Rent/Cloud

  • Rent for 48h to view
  • Buy Cloud Access for unlimited viewing via different devices
  • Synchronizing in the ReadCube Cloud
  • Printing and saving restrictions apply
Rental: USD 8.50
Cloud: USD 20.00

Select

Subscribe

  • Access to all articles of the subscribed year(s) guaranteed for 5 years
  • Unlimited re-access via Subscriber Login or MyKarger
  • Unrestricted printing, no saving restrictions for personal use
read more

Subcription rates

Select
* The final prices may differ from the prices shown due to specifics of VAT rules.

Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: December 18, 2009
Accepted: March 05, 2010
Published online: July 21, 2010
Issue release date: November 2010

Number of Print Pages: 12
Number of Figures: 1
Number of Tables: 5

ISSN: 1663-2818 (Print)
eISSN: 1663-2826 (Online)

For additional information: https://www.karger.com/HRP

Abstract

Background/Aims: The assessment of bone mineral content (BMC) and density (BMD) status in children and adolescents is important for health and the prevention of diseases. Bone metabolic activity could provide early information on bone mass development. Our aim was to describe bone mass and metabolism markers according to age and Tanner stage in adolescents. Methods: Spanish adolescents (n = 345; 168 males and 177 females) aged 12.5–17.5 years participated in this cross-sectional study. Body composition variables were measured by dual-energy X-ray absorptiometry. Serum osteocalcin (n = 101), aminoterminal propeptide of type I procollagen (n = 92) and β-isomerized C-telopeptides (β-CTX, n = 65) and urine samples (β-CTX; n = 237) were analyzed by electrochemiluminescence immunoassay. Results: Analysis of covariance showed that females had higher values for BMC and BMD in most of the regions. Both males and females had a significant decrease in bone markers while sexual maturation increases (all p < 0.05). Males had an increased bone turnover compared to females (all p < 0.05, except for urine β-CTX in Tanner ≤IV). Conclusion: Our results support the evidence of dimorphic site-specific bone accretion between sexes and show an increased bone turnover in males, suggesting higher metabolic activity.

© 2010 S. Karger AG, Basel



Related Articles:

References

  1. Rizzoli R, Bonjour JP: Determinants of peak bone mass and mechanisms of bone loss. Osteoporos Int 1999;9(suppl 2):S17–S23.
    External Resources
  2. Hui SL, Slemenda CW, Johnston CC Jr: The contribution of bone loss to postmenopausal osteoporosis. Osteoporos Int 1990;1:30–34.
    External Resources
  3. Bailey DA, McKay HA, Mirwald RL, Crocker PR, Faulkner RA: A six-year longitudinal study of the relationship of physical activity to bone mineral accrual in growing children: the University of Saskatchewan bone mineral accrual study. J Bone Miner Res 1999;14:1672–1679.
    External Resources
  4. Gordon CL, Halton JM, Atkinson SA, Webber CE: The contributions of growth and puberty to peak bone mass. Growth Dev Aging 1991;55:257–262.
    External Resources
  5. MacKelvie KJ, Khan KM, McKay HA: Is there a critical period for bone response to weight-bearing exercise in children and adolescents? A systematic review. Br J Sports Med 2002;36:250–257.
    External Resources
  6. Derman O, Cinemre A, Kanbur N, Dogan M, Kilic M, Karaduman E: Effect of swimming on bone metabolism in adolescents. Turk J Pediatr 2008;50:149–154.
    External Resources
  7. Moreno LA, Gonzalez-Gross M, Kersting M, Molnar D, de Henauw S, Beghin L, Sjostrom M, Hagstromer M, Manios Y, Gilbert CC, Ortega FB, Dallongeville J, Arcella D, Warnberg J, Hallberg M, Fredriksson H, Maes L, Widhalm K, Kafatos AG, Marcos A: Assessing, understanding and modifying nutritional status, eating habits and physical activity in European adolescents: the HELENA (Healthy Lifestyle in Europe by Nutrition in Adolescence) Study. Public Health Nutr 2008;11:288–299.
    External Resources
  8. De Henauw S, Gottrand F, De Bourdeaudhuij I, Gonzalez-Gross M, Leclercq C, Kafatos A, Molnar D, Marcos A, Castillo M, Dallongeville J, Gilbert C, Bergman P, Widhalm K, Manios Y, Breidenassel C, Kersting M, Moreno Lobot HSG: Nutritional status and lifestyles of adolescents in a public health perspective. The HELENA Project – Healthy Lifestyle in Europe by Nutrition in Adolescence. J Publ Health 2007;15:187–197.
    External Resources
  9. Ferrari SL: Osteoporosis: a complex disorder of aging with multiple genetic and environmental determinants. World Rev Nutr Diet 2005;95:35–51.
    External Resources
  10. Bailey DA, Faulkner RA, McKay HA: Growth, physical activity, and bone mineral acquisition. Exerc Sport Sci Rev 1996;24:233–266.
    External Resources
  11. Lehtonen-Veromaa M, Mottonen T, Irjala K, Nuotio I, Leino A, Viikari J: A 1-year prospective study on the relationship between physical activity, markers of bone metabolism, and bone acquisition in peripubertal girls. J Clin Endocrinol Metab 2000;85:3726–3732.
    External Resources
  12. Delmas PD: Biochemical markers of bone turnover. Acta Orthop Scand Suppl 1995;266:176–182.
    External Resources
  13. Burgeson RE: New collagens, new concepts. Annu Rev Cell Biol 1988;4:551–577.
    External Resources
  14. Fledelius C, Johnsen AH, Cloos PA, Bonde M, Qvist P: Characterization of urinary degradation products derived from type I collagen. Identification of a beta-isomerized Asp-Gly sequence within the C-terminal telopeptide (alpha1) region. J Biol Chem 1997;272:9755–9763.
    External Resources
  15. Garnero P, Fledelius C, Gineyts E, Serre CM, Vignot E, Delmas PD: Decreased beta-isomerization of the C-terminal telopeptide of type I collagen alpha 1 chain in Paget’s disease of bone. J Bone Miner Res 1997;12:1407–1415.
    External Resources
  16. Kraenzlin ME, Seibel MJ: Measurement of biochemical markers of bone resorption; in Seibel MJ, Robins SP, Bilezikian JP (eds): Dynamics of Bone and Cartilage Metabolism. San Diego, Academic Press, 1999, pp 411–426.
  17. Campion JM, Maricic MJ: Osteoporosis in men. Am Fam Physician 2003;67:1521–1526.
    External Resources
  18. Moreno LA, De Henauw S, Gonzalez-Gross M, Kersting M, Molnar D, Gottrand F, Barrios L, Sjostrom M, Manios Y, Gilbert CC, Leclercq C, Widhalm K, Kafatos A, Marcos A: Design and implementation of the Healthy Lifestyle in Europe by Nutrition in Adolescence Cross-Sectional Study. Int J Obes (Lond) 2008;32(suppl 5):S4–S11.
    External Resources
  19. Beghin L, Castera M, Manios Y, Gilbert CC, Kersting M, De Henauw S, Kafatos A, Gottrand F, Molnar D, Sjostrom M, Leclercq C, Widhalm K, Mesana MI, Moreno LA, Libersa C: Quality assurance of ethical issues and regulatory aspects relating to good clinical practices in the HELENA Cross-Sectional Study. Int J Obes (Lond) 2008;32(suppl 5): S12–S18.
    External Resources
  20. Lohman TM: Assessment of body composition in children. Pediatr Exerc Sci 1989;1:19–30.
    External Resources
  21. Moreno LA, Rodriguez G, Guillen J, Rabanaque MJ, Leon JF, Arino A: Anthropometric measurements in both sides of the body in the assessment of nutritional status in prepubertal children. Eur J Clin Nutr 2002;56:1208–1215.
    External Resources
  22. Moreno LA, Joyanes M, Mesana MI, Gonzalez-Gross M, Gil CM, Sarria A, Gutierrez A, Garaulet M, Perez-Prieto R, Bueno M, Marcos A: Harmonization of anthropometric measurements for a multicenter nutrition survey in Spanish adolescents. Nutrition 2003;19:481–486.
    External Resources
  23. Slaughter MH, Lohman TG, Boileau RA, Horswill CA, Stillman RJ, Van Loan MD, Bemben DA: Skinfold equations for estimation of body fatness in children and youth. Hum Biol 1988;60:709–723.
    External Resources
  24. Tanner JM, Whitehouse RH: Clinical longitudinal standards for height, weight, height velocity, weight velocity, and stages of puberty. Arch Dis Child 1976;51:170–179.
    External Resources
  25. Calbet JA, Dorado C, Diaz-Herrera P, Rodriguez-Rodriguez LP: High femoral bone mineral content and density in male football (soccer) players. Med Sci Sports Exerc 2001;33:1682–1687.
    External Resources
  26. Vicente-Rodriguez G, Ara I, Perez-Gomez J, Dorado C, Calbet JA: Muscular development and physical activity as major determinants of femoral bone mass acquisition during growth. Br J Sports Med 2005;39:611–616.
    External Resources
  27. Vereecken CA, Covents M, Sichert-Hellert W, Alvira JM, Le Donne C, De Henauw S, De Vriendt T, Phillipp MK, Beghin L, Manios Y, Hallstrom L, Poortvliet E, Matthys C, Plada M, Nagy E, Moreno LA: Development and evaluation of a self-administered computerized 24-h dietary recall method for adolescents in Europe. Int J Obes (Lond) 2008;32(suppl 5):S26–S34.
    External Resources
  28. Farrán A, Zamora R, Cervera P: Tablas de Composición de Alimentos del Centre d’Ensenyament Superior de Nutrició i Dietètica (CESNID). Barcelona, 2004.
  29. Nakagawa S, Cuthill IC: Effect size, confidence interval and statistical significance: a practical guide for biologists. Biol Rev Camb Philos Soc 2007;82:591–605.
    External Resources
  30. Seeman E: Clinical review 137: sexual dimorphism in skeletal size, density, and strength. J Clin Endocrinol Metab 2001;86:4576–4584.
    External Resources
  31. Zhang XZ, Kalu DN, Erbas B, Hopper JL, Seeman E: The effects of gonadectomy on bone size, mass, and volumetric density in growing rats are gender-, site-, and growth hormone-specific. J Bone Miner Res 1999;14:802–809.
    External Resources
  32. Kelly PJ, Eisman JA, Sambrook PN: Interaction of genetic and environmental influences on peak bone density. Osteoporos Int 1990;1:56–60.
    External Resources
  33. Yilmaz D, Ersoy B, Bilgin E, Gumuser G, Onur E, Pinar ED: Bone mineral density in girls and boys at different pubertal stages: relation with gonadal steroids, bone formation markers, and growth parameters. J Bone Miner Metab 2005;23:476–482.
    External Resources
  34. Vicente-Rodriguez G: How does exercise affect bone development during growth? Sports Med 2006;36:561–569.
    External Resources
  35. Lima F, De Falco V, Baima J, Carazzato JG, Pereira RM: Effect of impact load and active load on bone metabolism and body composition of adolescent athletes. Med Sci Sports Exerc 2001;33:1318–1323.
    External Resources
  36. De Schepper J, Derde MP, Van den Broeck M, Piepsz A, Jonckheer MH: Normative data for lumbar spine bone mineral content in children: influence of age, height, weight, and pubertal stage. J Nucl Med 1991;32:216–220.
    External Resources
  37. del Rio L, Carrascosa A, Pons F, Gusinye M, Yeste D, Domenech FM: Bone mineral density of the lumbar spine in white Mediterranean Spanish children and adolescents: changes related to age, sex, and puberty. Pediatr Res 1994;35:362–366.
    External Resources
  38. Goslings WR, Cole TJ, Prentice A, Bishop NJ: Rate of radial bone mineral accretion in healthy children. Acta Paediatr 1995;84:383–387.
    External Resources
  39. Rubin K, Schirduan V, Gendreau P, Sarfarazi M, Mendola R, Dalsky G: Predictors of axial and peripheral bone mineral density in healthy children and adolescents, with special attention to the role of puberty. J Pediatr 1993;123:863–870.
    External Resources
  40. Slemenda CW, Reister TK, Hui SL, Miller JZ, Christian JC, Johnston CC Jr: Influences on skeletal mineralization in children and adolescents: evidence for varying effects of sexual maturation and physical activity. J Pediatr 1994;125:201–207.
    External Resources
  41. Hasanoglu A, Tumer L, Ezgu FS: Vertebra and femur neck bone mineral density values in healthy Turkish children. Turk J Pediatr 2004;46:298–302.
    External Resources
  42. Vicente-Rodriguez G, Jimenez-Ramirez J, Ara I, Serrano-Sanchez JA, Dorado C, Calbet JA: Enhanced bone mass and physical fitness in prepubescent footballers. Bone 2003;33:853–859.
    External Resources
  43. Vicente-Rodriguez G, Ara I, Perez-Gomez J, Serrano-Sanchez JA, Dorado C, Calbet JA: High femoral bone mineral density accretion in prepubertal soccer players. Med Sci Sports Exerc 2004;36:1789–1795.
    External Resources
  44. Meier C, Seibel MJ, Kraenzlin ME: Use of bone turnover markers in the real world: are we there yet? J Bone Miner Res 2009;24:386–388.
    External Resources
  45. Blumsohn A, Hannon RA, Wrate R, Barton J, al-Dehaimi AW, Colwell A, Eastell R: Biochemical markers of bone turnover in girls during puberty. Clin Endocrinol (Oxf) 1994;40:663–670.
    External Resources
  46. Mora S, Prinster C, Proverbio MC, Bellini A, de Poli SC, Weber G, Abbiati G, Chiumello G: Urinary markers of bone turnover in healthy children and adolescents: age-related changes and effect of puberty. Calcif Tissue Int 1998;63:369–374.
    External Resources
  47. Mora S, Pitukcheewanont P, Kaufman FR, Nelson JC, Gilsanz V: Biochemical markers of bone turnover and the volume and the density of bone in children at different stages of sexual development. J Bone Miner Res 1999;14:1664–1671.
    External Resources
  48. van Coeverden SC, Netelenbos JC, de Ridder CM, Roos JC, Popp-Snijders C, Delemarre-van de Waal HA: Bone metabolism markers and bone mass in healthy pubertal boys and girls. Clin Endocrinol (Oxf) 2002;57:107–116.
    External Resources

Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: December 18, 2009
Accepted: March 05, 2010
Published online: July 21, 2010
Issue release date: November 2010

Number of Print Pages: 12
Number of Figures: 1
Number of Tables: 5

ISSN: 1663-2818 (Print)
eISSN: 1663-2826 (Online)

For additional information: https://www.karger.com/HRP

Copyright / Drug Dosage / Disclaimer

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

Article Tools
Article Details

2010, Vol.74, No. 5

November 2010

Article

Recommend This
TOP