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Original Paper

MRI Findings May Predict Early Neurologic Deterioration in Acute Minor Stroke or Transient Ischemic Attack due to Intracranial Atherosclerosis

Kim J.-T.a · Kim H.-J.b · Yoo S.-H.b · Park M.-S.a · Kwon S.U.b · Cho K.-H.a · Kim J.S.b · Kang D.-W.b

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Departments of Neurology,aChonnam National University Hospital, Gwangju, and bAsan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea

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Eur Neurol 2010;64:95–100

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: March 25, 2010
Accepted: May 18, 2010
Published online: July 09, 2010
Issue release date: August 2010

Number of Print Pages: 6
Number of Figures: 2
Number of Tables: 3

ISSN: 0014-3022 (Print)
eISSN: 1421-9913 (Online)

For additional information: https://www.karger.com/ENE

Abstract

Background: Patients with intracranial atherosclerosis (ICAS) are at high risk of early recurrence or neurologic deterioration. Although minor stroke and transient ischemic attack (TIA) seem benign, their occurrence in patients with ICAS may lead to early neurological deterioration (END). We aimed to identify factors associated with END in ICAS patients presenting with acute minor stroke or TIA, with a focus on early MRI findings. Methods: This was a retrospective analysis of consecutive patients with acute minor stroke or TIA admitted within 12 h of symptom onset. Patients with moderate-severe stenosis of the middle cerebral artery or basilar artery (BA) were included. All patients underwent MRI, including diffusion-weighted imaging (DWI), and magnetic resonance angiography. DWI lesion patterns were classified as perforating artery infarcts, pial infarcts, territorial infarcts and border zone infarcts (BIs). END was diagnosed as an increase of ≧4 points on the National Institutes of Health Stroke Scale from baseline during the 1st week. Results: Of the 95 patients enrolled in the study, 14 (14.7%) developed END. Independent predictors of END were the presence of BIs on baseline DWI (odds ratio, OR, 7.21; 95% confidential interval, CI, 1.88–27.66; p = 0.004) and BA disease (OR, 4.33; 95% CI, 1.11–16.92; p = 0.035). Conclusions: ICAS patients with BI and BA disease are at high risk of END after minor stroke or TIA. Early radiological findings may be helpful in predicting END and guiding early treatment strategies.

© 2010 S. Karger AG, Basel


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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: March 25, 2010
Accepted: May 18, 2010
Published online: July 09, 2010
Issue release date: August 2010

Number of Print Pages: 6
Number of Figures: 2
Number of Tables: 3

ISSN: 0014-3022 (Print)
eISSN: 1421-9913 (Online)

For additional information: https://www.karger.com/ENE


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