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Clinical Study

Long-Term Benefit Sustained after Bilateral Pallidal Deep Brain Stimulation in Patients with Refractory Tardive Dystonia

Chang E.F.a · Schrock L.E.b · Starr P.A.a, c · Ostrem J.L.b, c

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Departments of aNeurological Surgery and bNeurology, University of California, and cDepartment of Veterans Affairs Parkinson’s Disease Research, Education and Clinical Center, San Francisco, Calif., USA

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Stereotact Funct Neurosurg 2010;88:304–310

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Article / Publication Details

First-Page Preview
Abstract of Clinical Study

Received: September 29, 2009
Accepted: April 11, 2010
Published online: June 24, 2010
Issue release date: September 2010

Number of Print Pages: 7
Number of Figures: 3
Number of Tables: 2

ISSN: 1011-6125 (Print)
eISSN: 1423-0372 (Online)

For additional information: https://www.karger.com/SFN

Abstract

Background/Aims: Tardive dystonia (TD) can be a highly disabling, permanent condition related to the use of dopamine-receptor-blocking medications. Our aim was to evaluate the long-term effect of bilateral pallidal deep brain stimulation (DBS) for TD. Methods: Five consecutive patients with disabling TD who underwent stereotactic placement of bilateral globus pallidus internus DBS leads were included. All patients had a history of mood disorder or schizophrenia previously treated with neuroleptic medication, with a mean duration of motor symptoms of 10.2 years. Dystonia severity was measured using the Burke-Fahn-Marsden Dystonia Rating Scale (BFMDRS) movement score by a blinded neurologist reviewing pre- and postoperative videotaped examinations. Results: The mean baseline movement BFMDRS score was 49.7 (range 20–88). Overall, we observed a mean reduction of 62% in the BFMDRS movement score within the first year after surgery. Persistent improvement in dystonia (71%) was seen at the last follow-up ranging from 2 to 8 years after surgery. Conclusion: Our experience suggests that pallidal DBS can be an effective therapy with long-term benefits for patients with TD.

© 2010 S. Karger AG, Basel


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Article / Publication Details

First-Page Preview
Abstract of Clinical Study

Received: September 29, 2009
Accepted: April 11, 2010
Published online: June 24, 2010
Issue release date: September 2010

Number of Print Pages: 7
Number of Figures: 3
Number of Tables: 2

ISSN: 1011-6125 (Print)
eISSN: 1423-0372 (Online)

For additional information: https://www.karger.com/SFN


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