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Original Paper

Functional Polymorphism of Cyclooxygenase-2 Gene (G–765C) in Depressive Patients

Gałecki P.a · Florkowski A.a · Bieńkiewicz M.b · Szemraj J.c

Author affiliations

Departments of aAdult Psychiatry, bQuality Control and Radiological Protection and cMedical Biochemistry, Medical University of Lodz, Lodz, Poland

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Neuropsychobiology 2010;62:116–120

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: August 25, 2009
Accepted: November 15, 2009
Published online: June 30, 2010
Issue release date: July 2010

Number of Print Pages: 5
Number of Figures: 1
Number of Tables: 1

ISSN: 0302-282X (Print)
eISSN: 1423-0224 (Online)

For additional information: https://www.karger.com/NPS

Abstract

Background: Depressive disorder (DD) is characterized by an inflammatory process and oxidative stress. Cyclooxygenase-2 (COX-2), the expression of which increases in depression, is an enzyme involved in inflammation and free radical processes. The aim of our study was to assess the correlation between single nucleotide polymorphism G–765C of the COX-2 gene and recurrent DD. Methods: The study was carried out in a group of 181 patients treated for recurrent DD, and in 149 healthy subjects of the control group (CG). Polymerase chain reaction/restriction fragment length polymorphism was used for genotyping. Results: A statistically significant difference in genotype distribution was observed as a result of the comparison between the CG and the patients with DD. We demonstrated that the presence of the –765G allele in the COX-2 gene increased 2.1-fold the risk of DD development, whereas the presence of a homozygote (G–765G) in the analyzed gene increased the risk of DD development 2.5-fold. Conclusion: According to the obtained results, it may be proposed with some caution that the presence of both the –765G allele and the G–765G genotype in the COX-2 gene may confer a susceptibility to an increased risk of recurrent DD in the Polish population.

© 2010 S. Karger AG, Basel


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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: August 25, 2009
Accepted: November 15, 2009
Published online: June 30, 2010
Issue release date: July 2010

Number of Print Pages: 5
Number of Figures: 1
Number of Tables: 1

ISSN: 0302-282X (Print)
eISSN: 1423-0224 (Online)

For additional information: https://www.karger.com/NPS


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