Diabetic Mastopathy: A Case Report and Literature ReviewNeetu G.a · Pathmanathan R.a · Weng N.K.b
aDepartment of Pathology, Monash University Sunway Campus, Bandar Sunway, Selangor, bDepartment of Surgery, Kuantan Specialist Hospital, Kuantan, Pahang, Malaysia
Department of Pathology, Monash University Sunway Campus, Bandar Sunway
Subang Jaya, Selangor 46150 (Malaysia)
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Diabetic mastopathy is a rare fibroinflammatory breast disease characterized by lymphocytic lobulitis, ductitis, and perivasculitis with stromal fibrosis. This lesion often presents as a discretely palpable uni- or bilateral mass in long-standing type I diabetes and other autoimmune diseases. We report a case of insulin-dependent diabetic mastopathy, which presented clinically as an indeterminate breast lump suspicious for malignancy. The patient is a 36-year-old woman who had type 1 insulin-dependent diabetes mellitus. Mammography and ultrasonography raised a suspicion of malignancy, and an excisional biopsy was performed. A previous biopsy had shown no evidence of malignancy. Histopathological examination now showed dense keloid-like stromal fibrosis with epithelioid-like and spindly myofibroblasts and a characteristic lymphocytic infiltration around blood vessels in and around lobules and ducts, features consistent with diabetic mastopathy. The literature is briefly reviewed.
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