Dementia and Geriatric Cognitive Disorders

Original Research Article

Free Access

Absolute Quantification in Proton Magnetic Resonance Spectroscopy Is Useful to Differentiate Amnesic Mild Cognitive Impairment from Alzheimer’s Disease and Healthy Aging

Watanabe T.a, c · Shiino A.b, c · Akiguchi I.a, d

Author affiliations

aDepartment of Neurology, Uji-Takeda Hospital, Uji, bBiomedical MR Science Center and cCenter of Neurological Diseases, Shiga University of Medical Science, Otsu, and dCenter of Neurological and Cerebrovascular Diseases, Takeda Hospital, Kyoto, Japan

Corresponding Author

Toshiyuki Watanabe

Uji-Takeda Hospital

Uji-Satojiri 36-26

Uji, Kyoto 611-0021 (Japan)

Tel. +81 774 25 2500, Fax +81 774 25 2353, E-Mail tw1019@ya2.so-net.ne.jp

Keywords: Amnesic mild cognitive impairmentAlzheimer’s diseaseProton magnetic resonance spectroscopyN-acetylaspartateCholine compounds

Related Articles for ""
Dement Geriatr Cogn Disord 2010;30:71–77
https://doi.org/10.1159/000318750

Abstract

Background/Aims: Amnesic mild cognitive impairment (aMCI) is thought to represent a transitional state between healthy aging and very mild Alzheimer’s disease (AD). It is very important to diagnose aMCI for early treatment. In order to investigate biochemical changes in aMCI, we measured metabolite concentrations using proton magnetic resonance spectroscopy (1H-MRS) from patients with aMCI and compared the results with healthy controls (HCs) and patients with AD. Methods: The subjects were 52 HCs, 70 AD patients and 47 aMCI patients. 1H-MR spectra with single-voxel point-resolved spectroscopy at a short echo time (TE) were acquired from 8 volumes of interest in the brain. Results: The bilateral hippocampal N-acetylaspartate (NAA) concentrations from aMCI patients showed intermediate values, which were lower than those from HC subjects but higher than those from AD patients. The patients with aMCI also had lower concentrations of NAA than HCs in the bilateral posterior periventricular and deep white matters (PDWM) and posterior cingulate gyrus and had lower levels of choline compounds in the left posterior PDWM. Conclusion: Using a single-voxel 1H-MRS at a short TE, we revealed that absolute quantification is useful to detect the characteristic patterns of metabolite concentrations in patients with aMCI as compared with AD patients and HCs.

© 2010 S. Karger AG, Basel



Related Articles:

References

  1. Grundman M, Petersen RC, Ferris SH, Thomas RG, Alsen PS, Bennet DA, et al: Mild cognitive impairment can be distinguished from Alzheimer disease and normal aging for clinical trials. Arch Neurol 2004;61:59–66.
    External Resources
  2. Chetelat G, Desgranges B, de la Sayette V, Viader F, Eustache F, Baron JC: Mild cognitive impairment: can FDG-PET predict who is to rapidly convert to Alzheimer’s disease? Neurology 2003;60:1374–1377.
    External Resources
  3. Drzezga A, Lautenschlager N, Siebner H, Riemenschneider M, Willoch F, Minoshima S, et al: Cerebral metabolic changes accompanying conversion of mild cognitive impairment into Alzheimer’s disease: a PET follow-up study. Eur J Nucl Med Mol Imaging 2003;30:1104–1113.
    External Resources
  4. Kantarci K, Jack CR, Xu YC, Campeau NG, O’Brien PC, Smith GE, et al: Regional metabolic patterns in mild cognitive impairment and Alzheimer’s disease: a 1H MRS study. Neurology 2000;25:210–217.
  5. Kantarci K, Xu YC, Shiung MM, O’Brien PC, Cha RH, Smith GE, et al: Comparative diagnostic utility of different MR modalities in mild cognitive impairment and Alzheimer’s disease. Dementia Geriatr Cogn Disord 2002;14:198–207.
    External Resources
  6. Kantarci K, Reynolds G, Xu YC, Petersen RC, Boeve BF, Knopman D, et al: Proton MR spectroscopy in mild cognitive impairment and Alzheimer disease: comparison of 1.5 and 3T. AJNR Am J Neuroradiol 2003;24:843–849.
    External Resources
  7. Kantarci K, Petersen RC, Boeve BF, Knopman DS, Tang-Wai DF, O’Brien PC, et al: 1H MR spectroscopy in common dementias. Neurology 2004;63:1393–1398.
    External Resources
  8. Kantarci K, Weigand SD, Petersen RC, Boeve BF, Knopman DS, Gunter J, et al: Longitudinal 1H MRS changes in mild cognitive impairment and Alzheimer’s disease. Neurobiol Aging 2006;28:1330–1339.
    External Resources
  9. Kantarci K, Weigand SD, Przybelski SA, Shiung MM, Whitwell JL, Negash S, et al: Risk of dementia in MCI: combined effect of cerebrovascular disease, volumetric MRI, and 1H MRS. Neurology 2009;72:1519–1525.
    External Resources
  10. Catani M, Cherubini A, Howard R, Tarducci R, Pelliccioli GP, Piccirilli M, et al: 1H-MR spectroscopy differentiates mild cognitive impairment from normal brain aging. Neuroreport 2003;12:2315–2317.
    External Resources
  11. Chantal S, Braun CM, Bouchard RW, Labelle M, Boulanger Y: Similar 1H magnetic resonance spectroscopic metabolic pattern in the medial temporal lobes of patients with mild cognitive impairment and Alzheimer disease. Brain Res 2004;1003:26–35.
    External Resources
  12. Martinez-Bisbal MC, Arana E, Marti-Bonmati L, Molla E, Celda B: Cognitive impairment: classification by 1H magnetic resonance spectroscopy. Eur J Neurol 2004;11:187–193.
    External Resources
  13. Ackl N, Ising M, Schreiber YA, Atiya M, Sonntag A, Auer D: Hippocampal metabolic abnormalities in mild cognitive impairment and Alzheimer’s disease. Neurosci Lett 2005;384:23–28.
    External Resources
  14. Chao LL, Schuff N, Kramer JH, Du AT, Capizzano AA, O’Neill J, et al: Reduced medial temporal lobe N-acetylaspartate in cognitively impaired nondemented patients. Neurology 2005;64:282–289.
    External Resources
  15. Falini A, Bozzali M, Magnani G, Pero G, Gambini A, Benedetti B, et al: A whole brain MR spectroscopy study from patients with Alzheimer’s disease and mild cognitive impairment. Neuroimage 2005;26:1159–1163.
    External Resources
  16. Modrego PJ, Fayed N, Pina MA: Conversion from mild cognitive impairment to probable Alzheimer’s disease predicted by brain magnetic resonance spectroscopy. Am J Psychiatry 2005;162:667–675.
    External Resources
  17. Metastasio A, Rinaldi P, Tarducci R, Mariani E, Feliziani FT, Cherubini A, et al: Conversion of MCI to dementia: role of proton magnetic resonance spectroscopy. Neurobiol Aging 2006;27:926–932.
    External Resources
  18. Perneczky R, Hartmann J, Grimmer T, Drzezga A, Kurz A: Cerebral metabolic correlates of the clinical dementia rating scale in mild cognitive impairment. J Geriatr Psychiatry Neurol 2007;20:84–88.
    External Resources
  19. Garcia Santos JM, Gavrilla D, Antunez C, Tormo MJ, Salmeron D, Carles R, et al: Magnetic resonance spectroscopy performance for detection of dementia, Alzheimer’s disease and mild cognitive impairment in a community-based survey. Dementia Geriatr Cogn Disord 2008;26:15–25.
    External Resources
  20. Jessen F, Gur O, Block W, Ende G, Frolich L, Hammen T, et al: A multicenter 1H-MRS study of the medial temporal lobe in AD and MCI. Neurology 2009;72:1735–1740.
    External Resources
  21. Zhang B, Li M, Sun ZZ, Zhu B, Yuan L, Wang Y, et al: Evaluation of functional MRI markers in mild cognitive impairment. J Clin Neurosci 2009;16:635–641.
    External Resources
  22. Rupsingh R, Borrie M, Smith M, Wells JL, Bartha R: Reduced hippocampal glutamate in Alzheimer disease. Neurobiol Aging 2009, E-pub ahead of print.
  23. Valenzuela MJ, Sachdev P: Magnetic resonance spectroscopy in Alzheimer’s disease. Neurology 2001;56:592–598.
    External Resources
  24. Moffett JR, Ross B, Arun P, Madhavarao CN, Namboodiri AMA: N-acetylaspartate in the CNS: from neurodiagnostics to neurobiology. Prog Neurobiol 2007;81:89–131.
    External Resources
  25. Watanabe T, Akiguchi I, Yagi H, Onishi K, Kawasaki T, Shiino A, et al: Proton magnetic resonance spectroscopy and white matter hyperintensities on magnetic resonance imaging in patients with Alzheimer’s disease. Ann NY Acad Sci 2002;977:423–429.
    External Resources
  26. Watanabe T, Shiino A, Akiguchi I: Absolute quantification in proton magnetic resonance spectroscopy is superior to relative ratio to discriminate Alzheimer’s disease from Binswanger’s disease. Dement Geriatr Cogn Disord 2008;26:89–100.
    External Resources
  27. Provencher SW: Estimation of metabolite concentrations from localized in vivo proton NMR spectra. Magn Reson Med 1993;30:672–679.
    External Resources
  28. American Psychiatric Association: Diagnostic and Statistical Manual of Mental Disorders, ed 4. Washington, American Psychiatric Association, 1994.
  29. McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM: Clinical diagnosis of Alzheimer’s disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer’s disease. Neurology 1984;34:939–944.
    External Resources
  30. Morris JC: The Clinical Dementia Rating (CDR): current version and scoring rules. Neurology 1993;43:2412–2414.
    External Resources
  31. Folstein MF: Mini Mental State: a practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975;12:189–198.
    External Resources
  32. Shinagawa F, Kobayashi S, Fujita K, Maekawa H: Japanese Wechsler Adult Intelligence Scale Revised (in Japanese). Tokyo, Nihon Bunka Kagakusha, 1990.
  33. Sugishita M: Japanese Wechsler Memory Scale Revised (in Japanese). Tokyo, Nihon Bunka Kagakusha, 2001.
  34. Kreis R, Ernst T, Ross BD: Absolute quantification of water and metabolites in the human brain. 2. Metabolite concentrations. J Magn Reson Ser B 1993;102:9–19.
    External Resources
  35. Choi CG, Frahm J: Localized proton MRS of the human hippocampus: metabolite concentrations and relaxation times. Magn Reson Med 1999;41:204–207.
    External Resources
  36. Jessen F, Block W, Traber F, Keller E, Flacke S, Papassotiropoulos A, et al: Proton MR spectroscopy detects a relative decrease of N-acetylaspartate in the medial temporal lobe of patients with AD. Neurology 2000;55:684–688.
    External Resources
  37. Jessen F, Block W, Traber F, Keller E, Flacke S, Lamerichs R, et al: Decrease of N-acetylaspartate in the MTL correlates with cognitive decline of AD. Neurology 2001;57:930–932.
    External Resources
  38. Franczak M, Prost RW, Antuouno PG, Mark LP, Jones JL, Ulmer JL: Proton magnetic resonance spectroscopy of the hippocampus in patients with mild cognitive impairment: a pilot study. J Comp Assist Tomogr 2007;31:666–670.
    External Resources
  39. Wang XC, Du XX, Tian Q, Wang JZ: Correlation between choline signal intensity and acetylcholine level in different brain regions of rat. Neurochem Res 2008;33:814–819.
    External Resources

Article / Publication Details

First-Page Preview
Abstract of Original Research Article

Accepted: June 17, 2010
Published online: June 17, 2010
Issue release date: August 2010

Number of Print Pages: 7
Number of Figures: 2
Number of Tables: 2

ISSN: 1420-8008 (Print)
eISSN: 1421-9824 (Online)

For additional information: https://www.karger.com/DEM

Copyright / Drug Dosage / Disclaimer

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

Article Tools
Article Details

2010, Vol.30, No. 1

August 2010

Article

Recommend This
TOP