Are IgE Levels to Foods other than Rosaceae Predictive of Allergy in Lipid Transfer Protein-Hypersensitive Patients?Asero R.a · Arena A.b · Cecchi L.c · Conte M.E.d · Crivellaro M.e · Emiliani F.f · Lodi Rizzini F.g · Longo R.h · Minale P.i · Murzilli F.j · Musarra A.k · Nebiolo F.l · Quercia O.f · Ridolo E.m · Savi E.n · Senna G.E.d · Villalta D.o
aAmbulatorio di Allergologia, Clinica San Carlo, Paderno Dugnano, bAmbulatorio di Allergologia, ASP Messina, Messina, cAmbulatorio di Allergologia, Azienda Sanitaria 10, Firenze, dUO Allergologia, Azienda Ospedaliera, Verona, eServizio di Allergologia, Dipartimento di Medicina Ambientale e Salute Pubblica, Università di Padova, Padova, fAmbulatorio di Allergologia, Dipartimento di Medicina Interna, Ospedale di Faenza, Faenza, gSSVD Allergologia – Spedali Civili, Brescia, hAzienda Sanitaria Provinciale, Vibo Valenzia, iDipartimento di Allergologia, Ospedale San Martino, Genova, jUO Allergologia, Ospedale SS Filippo e Nicola, Avezzano, kAmbulatorio di Allergologia, Azienda Sanitaria Provinciale, Reggio Calabria, lAmbulatorio di Allergologia e Immunologia, AO Ordine Mauriziano, Torino, mDipartimento di Scienze Cliniche, Università di Parma, Parma, nUO Allergologia, Ospedale G. da Salicelto, AUSL Piacenza, Piacenza, and oAllergologia e Immunologia Clinica, Dipartimento di Medicina di Laboratorio, AO S. Maria degli Angeli, Pordenone, Italy
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Article / Publication Details
Background: Lipid transfer protein (LTP), the most frequent cause of primary food allergy in Italy, is a cross-reacting plant pan-allergen. Markers able to predict whether a patient sensitized to a certain food but not yet clinically allergic will develop allergy would be extremely helpful. Objective: It was the aim of this study to investigate the relevance of IgE levels to some plant foods other than Rosaceae as predictors of either local or systemic allergic reaction in LTP-allergic subjects. Methods: One hundred (40 males, 60 females , mean age 29 years) peach-allergic patients monosensitized to LTP seen at 14 Italian centres in 2009 were studied. Walnut, hazelnut, peanut, tomato, rice and/or maize allergy was ascertained by interview and confirmed by positive skin prick test. IgE levels to these foods and to rPru p 3 were measured. Results: Higher levels of IgE to Pru p 3 were associated with a higher prevalence of allergy to hazelnut, peanut and walnut. For all study foods, except rice, median IgE levels in allergic subjects significantly exceeded those in tolerant subjects, though within single allergic groups, the differences between patients reporting systemic or local (oral) symptoms were not significant. Ninety-five percent cut-off IgE levels predictive of clinical allergy were established for study foods although the marked overlaps between allergic and tolerant subjects made them of limited usefulness. Conclusion: Specific IgE levels are only partially predictive of clinical allergy. The reasons why some individuals showing low specific IgE levels develop clinical allergy whereas others showing high IgE levels do not, despite similar exposure to the allergen, remain unclear.
© 2010 S. Karger AG, Basel
- Asero R, Antonicelli L, Arena A, Bommarito L, Caruso B, et al: EpidemAAITO: features of food allergy in Italian adults attending allergy clinics: a multi-centre study. Clin Exp Allergy 2009;39:547–555.
- Asero R, Antonicelli L, Arena A, Bommarito L, Caruso B, et al: Causes of food-induced anaphylaxis in Italian adults: a multi-centre study. Int Arch Allergy Immunol 2009;150:271–277.
- Asero R, Mistrello G, Roncarolo D, Amato S, Caldironi G, Barocci F, van Ree R: Immunological cross-reactivity between lipid transfer proteins from botanically unrelated plant-derived foods: a clinical study. Allergy 2002;57:900–906.
- Sampson HA, Ho DG: Relationship between food-specific IgE concentrations and the risk of positive food challenges in children and adolescents. J Allergy Clin Immunol 1997;100:444–451.
- Sampson HA: Utility of food specific IgE concentrations in predicting symptomatic food allergy. J Allergy Clin Immunol 2001;107:891–896.
- Boyano Martinez T, Garcia-Ara C, Diaz-Pena JM, Martin-Esteban M: Prediction of tolerance on the basis of quantification of egg white-specific IgE antibodies in children with egg allergy. J Allergy Clin Immunol 2002;110:304–309.
- Garcia-Ara MC, Boyano-Martinez MT, Diaz-Pena JM, et al: Cow’s milk specific immunoglobulin E levels as predictors of clinical reactivity in the follow-up of the cow’s milk allergy infants. Clin Exp Allergy 2004;34:866–870.
- Shek LP, Soderstrom L, Ahlstedt S, et al: Determination of food specific IgE levels over time can predict the development of tolerance in cow’s milk and hen’s egg allergy. J Allergy Clin Immunol 2004;114:387–391.
Celik-Bigili S, Mehl A, Verstege A, Staden U, Nokon M, Beyer K, Niggemann B: The predictive value of specific immunoglobulin E levels in serum for the outcome of oral food challenges. Clin Exp Allergy 2005;35:268–273.
- Roberts G, Lack G: Diagnosing peanut allergy with skin prick and specific IgE testing. J Allergy Clin Immunol 2005;115:1291–1296.
- Maloney JM, Rudengren M, Ahlstedt S, Bock SA, Sampson HA: The use of serum-specific IgE measurements for the diagnosis of peanut, tree nut, and seed allergy. J Allergy Clin Immunol 2008;122:145–151.
- Dieguez MC, Cerecedo I, Muriel A, Zamora J, Abraira V, Camacho E, Anton M, del la Hoz B: Utility of diagnostic tests in the follow-up of egg-allergic children. Clin Exp Allergy 2009;39:1575–1584.
- Tripodi S, Di Rienzo Businco A, Alessandri C, Panetta V, Restani P, Matricardi PM: Predicting the outcome of oral food challenges with hen’s egg through skin test end-point titration. Clin Exp Allergy 2009;39:1225–1233.
- Asero R, Mistrello G, Roncarolo D, Amato S: Relationship between peach lipid transfer protein specific IgE levels and hypersensitivity to non-Rosaceae vegetable foods in patients allergic to lipid transfer protein. Ann Allergy Asthma Immunol 2004;92:268–272.
- Rossi RE, Monasterolo G, Canonica GW, Passalacqua G: Systemic reactions to peach are associated with high levels of specific IgE to Pru p 3. Allergy 2009;64:1795–1796.
- Schocker F, Luttkopf D, Scheurer S, Petersen A, Cistro Bahima A, Enrique E, et al: Recombinant lipid transfer protein Cor a 8 from hazelnut: a new tool for in-vitro diagnosis of potentially severe hazelnut allergy. J Allergy Clin Immunol 2004;113:141–147.
- Pastorello EA, Farioli L, Pravettoni V, Robino AM, Scibilia J, et al: Lipid transfer protein and vicilin are important walnut allergen in patients not allergic to pollen. J Allergy Clin Immunol 2004;114:908–914.
- Pastorello EA, Farioli L, Pravettoni V, Ispano M, et al: The maize major allergen, which is responsible for food-induced allergic reactions, is a lipid transfer protein. J Allergy Clin Immunol 2000;106:744–751.
- Asero R, Amato S, Alfieri B, Folloni S, Mistrello G: Rice: another potential cause of food allergy in patients sensitized to lipid transfer protein. Int Arch Allergy Immunol 2007;143:69–74.
- Lauer I, Dueringer N, Pokoj S, Rehm S, Zoccatelli G, Reese G, Miguel-Moncin MS, Cistero-Bahima A, Enrique E, Lidholm J, Vieths S, Scheurer S: The nonspecific lipid transfer protein, Ara h 9, is an important allergen in peanut. Clin Exp Allergy 2009;39:1427–1437.
Romano A, Fernandez-Rivas M, Caringi M, Amato S, Mistrello G, Asero R: Allergy to peanut lipid transfer protein: frequency and cross-reactivity between peanut and peach LTP. Eur Ann Allergy Clin Immunol 2009;41:106–111.
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