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Published: August 2010

Open Access Gateway

Hepatocellular Carcinoma with Foamy Histiocyte-Like Appearance: A Deceptively Clear Cell Carcinoma Appearing Variant

Noro T.a · Gotohda N.a · Kojima M.b · Konishi M.a · Nakaghori T.a · Takahashi S.a · Hasebe T.c · Kinoshita T.a

Author affiliations

aDepartment of Hepatobiliary Pancreatic Surgery, bPathology Division, Research Center for Innovative Oncology, and cSurgical Pathology Section, Clinical Laboratory Division, National Cancer Center Hospital East, Kashiwa, Japan

Corresponding Author

Takuji Noro, MD

Department of Surgery, International University of Health and Welfare Hospital

537-3 Iguchi Nasushiobara-shi, Tochigi 329-2763 (Japan)

Tel. +81 287 372 221, Fax +81 287 375 315, E-Mail tnoro@ihw.ac.jp

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Case Rep Gastroenterol 2010;4:286–292

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Hepatocellular carcinoma (HCC) shows many pathological features, and it varies architecturally and cytologically. There have been many reports and discussions of the morphological features of HCC. A 63-year-old man was found to have a solitary tumor in liver segment 7 that was diagnosed as HCC. A partial resection of liver segment 7 was performed. Microscopically, the tumor lesion showed a moderately differentiated HCC. There was also a lesion with foamy histiocyte-like cells corresponding to the white lesion in the face of the cut tumor. Immunohistochemical staining showed that they were negative for CD68, S-100, vimentin, and HMB-45. The cytoplasm itself was negative on periodic acid Schiff (PAS) and Sudan staining. Without immunohistological analysis, it is difficult to distinguish this HCC variant from clear cell carcinoma or metastases of renal cell carcinoma. It is important to recognize this type as a specific cytological variant of HCC that requires confirmation by immunohistochemistry. This report describes the case of a patient with a morphologically distinctive pattern of HCC with prominent cell cytoplasm that had a foamy histiocyte-like appearance. To the best of our knowledge, this is the first report of this HCC variant.

© 2010 S. Karger AG, Basel

Article / Publication Details

First-Page Preview
Abstract of Published: August 2010

Published online: August 03, 2010
Issue release date: May – August

Number of Print Pages: 7
Number of Figures: 3
Number of Tables: 1

eISSN: 1662-0631 (Online)

For additional information: http://www.karger.com/CRG

Open Access License / Drug Dosage / Disclaimer

Open Access License: This is an Open Access article licensed under the terms of the Creative Commons Attribution-NonCommercial 3.0 Unported license (CC BY-NC) (www.karger.com/OA-license), applicable to the online version of the article only. Distribution permitted for non-commercial purposes only.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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