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Original Paper

Normal Ranges of Embryonic Length, Embryonic Heart Rate, Gestational Sac Diameter and Yolk Sac Diameter at 6–10 Weeks

Papaioannou G.I. · Syngelaki A. · Poon L.C.Y. · Ross J.A. · Nicolaides K.H.

Author affiliations

Harris Birthright Research Centre for Fetal Medicine and Early Pregnancy Unit, King’s College Hospital, London, UK

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Fetal Diagn Ther 2010;28:207–219

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: May 10, 2010
Accepted: July 19, 2010
Published online: September 18, 2010
Issue release date: November 2010

Number of Print Pages: 13
Number of Figures: 9
Number of Tables: 7

ISSN: 1015-3837 (Print)
eISSN: 1421-9964 (Online)

For additional information: https://www.karger.com/FDT

Abstract

Objectives: To construct normal ranges for embryonic crown-rump length (CRL), heart rate (HR), gestational sac diameter (GSD) and yolk sac diameter (YSD) at 6–10 weeks of gestation. Methods: We examined 4,698 singleton pregnancies with ultrasound measurements of CRL, HR, GSD and YSD at 6–10 weeks and CRL at 11–13 weeks resulting in the live birth after 36 weeks of phenotypically normal neonates with birth weight above the 5th centile. Gestational age was derived from CRL at the 11- to 13-week scan using the formula of Robinson and Fleming. Regression analysis was used to establish normal ranges of CRL, fetal HR, GSD and YSD with gestation, and fetal HR, GSD and YSD with CRL. Results: At 6–10 weeks there were significant quadratic associations between CRL, GSD, YSD and gestation and between HR, GSD, YSD and CRL, and a cubic association between HR and gestation. The estimated gestation from CRL was the same as that of Robinson and Fleming for a CRL of 10.2–36.5 mm, but the formula of Robinson and Fleming underestimated the gestation by 1 day for a CRL 7.4–10.2 mm and this increased to 9 days for a CRL of 1 mm. Conclusion: This study established normal ranges for early pregnancy biometry.

© 2010 S. Karger AG, Basel


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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: May 10, 2010
Accepted: July 19, 2010
Published online: September 18, 2010
Issue release date: November 2010

Number of Print Pages: 13
Number of Figures: 9
Number of Tables: 7

ISSN: 1015-3837 (Print)
eISSN: 1421-9964 (Online)

For additional information: https://www.karger.com/FDT


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